| Name | PTPRF |
| ID | P10586 |
| Role | phosphatase |
| Enzymatic Domains |
Ig-like C2-type 1 33-123
Ig-like C2-type 2 135-224
Ig-like C2-type 3 232-314
Fibronectin type-III 1 321-411 PROSITE-ProRule
Fibronectin type-III 2 416-510 PROSITE-ProRule
Fibronectin type-III 3 514-604 PROSITE-ProRule
Fibronectin type-III 4 609-706 PROSITE-ProRule
Fibronectin type-III 5 711-819 PROSITE-ProRule
Fibronectin type-III 6 820-914 PROSITE-ProRule
Fibronectin type-III 7 918-1010 PROSITE-ProRule
Fibronectin type-III 8 1014-1098 PROSITE-ProRule
Tyrosine-protein phosphatase 1 1352-1607 PROSITE-ProRule
Tyrosine-protein phosphatase 2 1639-1898 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRF | EGFR | – | dephosphorylation down-regulates activity | 12018405 | SIGNOR-277029 | |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-76005 |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-76009 |
| PTPRF | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-76013 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-76017 |
| PTPRF | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 1303753 | SIGNOR-16235 |
| PTPRF | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 1303753 | SIGNOR-16239 |
| PTPRF | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1303753 | SIGNOR-16243 |
| PTPRF | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 1303753 | SIGNOR-16247 |
| PTPRF | LCK | – | dephosphorylation up-regulates | 12496362 | SIGNOR-96771 | |
| PTPRF | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 12496362 | SIGNOR-96768 |
| PTPRF | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates | 12496362 | SIGNOR-96764 |
| PTPRF | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 11121408 | SIGNOR-85170 |
| PTPRF | PLCG1 | – | dephosphorylation down-regulates | 11121408 | SIGNOR-85166 | |
| PTPRF | AKT1 | Ser473 | RPHFPQFsYSASGTA | dephosphorylation down-regulates | 15896785 | SIGNOR-137246 |
| PTPRF | DAPK1 | Tyr490 | HCAAWHGyYSVAKAL | dephosphorylation up-regulates | 17803936 | SIGNOR-157702 |
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates | 17803936 | SIGNOR-157706 |
| PTPRF | DAPK1 | Tyr490 | HCAAWHGyYSVAKAL | dephosphorylation up-regulates activity | 17803936 | SIGNOR-276076 |
| PTPRF | DAPK1 | Tyr491 | CAAWHGYySVAKALC | dephosphorylation up-regulates activity | 17803936 | SIGNOR-276075 |
| PTPRF | BCAR1 | – | dephosphorylation down-regulates quantity by destabilization | 10320483 | SIGNOR-276998 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76005 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76009 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76013 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-76017 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16235 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16239 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16243 |
| PTPRF | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 1303753 | SIGNOR-16247 |
| PTPRF | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 12496362 | SIGNOR-96768 |
| PTPRF | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 12496362 | SIGNOR-96764 |
| PTPRF | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 11121408 | SIGNOR-85170 |
| PTPRF | dephosphorylation down-regulates ⊣ | AKT1 PSer473 | dephosphorylation up-regulates → | AKT1 | 15896785 | SIGNOR-137246 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr490 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-157702 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-157706 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr490 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276076 |
| PTPRF | dephosphorylation down-regulates ⊣ | DAPK1 PTyr491 | dephosphorylation down-regulates ⊣ | DAPK1 | 17803936 | SIGNOR-276075 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRF | dephosphorylation → down-regulates activity | EGFR | SIGNOR-277029 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76005 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76009 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76013 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-76017 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16235 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16239 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16243 |
| PTPRF | dephosphorylation down-regulates | INSR | SIGNOR-16247 |
| PTPRF | dephosphorylation → up-regulates | LCK | SIGNOR-96771 |
| PTPRF | dephosphorylation down-regulates | FYN | SIGNOR-96768 |
| PTPRF | dephosphorylation → up-regulates | FYN | SIGNOR-96764 |
| PTPRF | dephosphorylation down-regulates | RET | SIGNOR-85170 |
| PTPRF | dephosphorylation down-regulates | PLCG1 | SIGNOR-85166 |
| PTPRF | dephosphorylation down-regulates | AKT1 | SIGNOR-137246 |
| PTPRF | dephosphorylation → up-regulates | DAPK1 | SIGNOR-157702 |
| PTPRF | dephosphorylation → up-regulates | DAPK1 | SIGNOR-157706 |
| PTPRF | dephosphorylation → up-regulates activity | DAPK1 | SIGNOR-276076 |
| PTPRF | dephosphorylation → up-regulates activity | DAPK1 | SIGNOR-276075 |
| PTPRF | dephosphorylation down-regulates quantity by destabilization | BCAR1 | SIGNOR-276998 |