| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHKG1 | MAPT | Ser622 | KHVPGGGsVQIVYKP | phosphorylation down-regulates activity | 8999860 | SIGNOR-250286 |
| DYRK1A | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates | 21215781 | SIGNOR-171038 |
| CDK5 | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249318 |
| GSK3B | MAPT | Ser512 | PPKSGDRsGYSSPGS | phosphorylation down-regulates activity | 9771888 | SIGNOR-249353 |
| PRKAA1 | MAPT | Ser355 | EADLPEPsEKQPAAA | phosphorylation down-regulates activity | 10090741 | SIGNOR-275440 |
| MARK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-250175 |
| PRKACA | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 12435421 | SIGNOR-250007 |
| GSK3B | MAPT | Ser717 | VYKSPVVsGDTSPRH | phosphorylation down-regulates activity | 12387894 | SIGNOR-249355 |
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-251601 |
| GSK3B | MAPT | Ser515 | SGDRSGYsSPGSPGT | phosphorylation down-regulates activity | 9832145 | SIGNOR-249354 |
| GSK3B | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249343 |
| MARK1 | MAPT | Ser641 | KVTSKCGsLGNIHHK | phosphorylation down-regulates | 21215781 | SIGNOR-171054 |
| MARK4 | MAPT | Ser420 | KHPTPGSsDPLIQPS | phosphorylation down-regulates activity | 21204788 | SIGNOR-273936 |
| MAPK12 | MAPT | Ser637 | VDLSKVTsKCGSLGN | phosphorylation down-regulates activity | 9199504 | SIGNOR-250085 |
| GSK3A | MAPT | – | phosphorylation down-regulates | 7566348 | SIGNOR-29364 | |
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171050 |
| CDK5/CDK5R1 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-251592 |
| CSNK1D | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 14761950 | SIGNOR-121717 |
| PP2B | MAPT | Ser516 | GDRSGYSsPGSPGTP | dephosphorylation up-regulates | 20308788 | SIGNOR-164659 |
| CDK5 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249327 |
| PP2B | MAPT | Ser579 | NVKSKIGsTENLKHQ | dephosphorylation up-regulates | 20308788 | SIGNOR-164663 |
| PINK1 | MAPT | – | phosphorylation down-regulates activity | 35059394 | SIGNOR-279250 | |
| CDK5/CDK5R1 | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates activity | 12387894 | SIGNOR-251595 |
| PKN1 | MAPT | Ser637 | VDLSKVTsKCGSLGN | phosphorylation down-regulates | 11104762 | SIGNOR-84958 |
| GSK3B | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249348 |
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 10090741 | SIGNOR-250172 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-251600 |
| GSK3B | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-249346 |
| PP2B | MAPT | Thr529 | TPGSRSRtPSLPTPP | dephosphorylation up-regulates | 20308788 | SIGNOR-164675 |
| GSK3B | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates | 17078951 | SIGNOR-150364 |
| AMPK | MAPT | Ser420 | KHPTPGSsDPLIQPS | phosphorylation down-regulates activity | 21204788 | SIGNOR-273931 |
| MAPK1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 10737616 | SIGNOR-249417 |
| CDK5 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249323 |
| MARK1 | MAPT | Ser641 | KVTSKCGsLGNIHHK | phosphorylation down-regulates activity | 10090741 | SIGNOR-250174 |
| TTBK1 | MAPT | Ser739 | GSIDMVDsPQLATLA | phosphorylation down-regulates | 16923168 | SIGNOR-148978 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-251593 |
| GSK3B | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates activity | 12387894 | SIGNOR-249349 |
| MAPK12 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 9199504 | SIGNOR-250084 |
| SYK | MAPT | Tyr18 | MEDHAGTyGLGDRKD | phosphorylation down-regulates | 18070606 | SIGNOR-159648 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249317 |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249322 |
| GSK3B | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249351 |
| PRKACA | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 12435421 | SIGNOR-250008 |
| MAPK1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 10737616 | SIGNOR-249416 |
| GSK3B | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249344 |
| GSK3B | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates | 20308788 | SIGNOR-164651 |
| PTEN | MAPT | – | dephosphorylation up-regulates activity | 27221467 | SIGNOR-277079 | |
| MAPK13 | MAPT | – | phosphorylation down-regulates activity | 9199504 | SIGNOR-278313 | |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171022 |
| PHKG1 | MAPT | Ser602 | INKKLDLsNVQSKCG | phosphorylation down-regulates activity | 8999860 | SIGNOR-250285 |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-249325 |
| TTBK1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates | 16923168 | SIGNOR-148970 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-92603 |
| MARK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation down-regulates | 21215781 | SIGNOR-171058 |
| MAPK1 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 10737616 | SIGNOR-249418 |
| CSNK1D | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 14761950 | SIGNOR-121713 |
| GSK3B | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 20679343 | SIGNOR-167294 |
| GSK3A | MAPT | Ser641 | KVTSKCGsLGNIHHK | phosphorylation down-regulates activity | 7706316 | SIGNOR-249342 |
| MAPK14 | MAPT | – | phosphorylation up-regulates | 20626350 | SIGNOR-166611 | |
| DYRK1A | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 21215781 | SIGNOR-171034 |
| NUAK1 | MAPT | Ser673 | RVQSKIGsLDNITHV | phosphorylation up-regulates quantity | 27720485 | SIGNOR-279306 |
| MARK2 | MAPT | – | phosphorylation down-regulates quantity | 36048712 | SIGNOR-280038 | |
| CAMK2A | MAPT | – | phosphorylation down-regulates | 15621017 | SIGNOR-255490 | |
| GSK3B | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 20308788 | SIGNOR-164655 |
| CDK5/CDK5R1 | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251589 |
| PP2B | MAPT | Thr522 | SSPGSPGtPGSRSRT | dephosphorylation up-regulates | 20308788 | SIGNOR-164671 |
| GSK3B | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60655 |
| MAPK12 | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 9199504 | SIGNOR-250086 |
| MAPK12 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 9199504 | SIGNOR-250088 |
| GSK3B | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249347 |
| GSK3B | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates | 20679343 | SIGNOR-167286 |
| AMPK | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates activity | 21204788 | SIGNOR-273926 |
| PRKAA1 | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates activity | 10090741 | SIGNOR-275439 |
| CDK5 | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates activity | 12387894 | SIGNOR-249324 |
| PHKG1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 8999860 | SIGNOR-250284 |
| CDK5/CDK5R1 | MAPT | Ser235 | SPQDSPPsKASPAQD | phosphorylation down-regulates | 21215781 | SIGNOR-251587 |
| GSK3B | MAPT | Ser400 | AKTSTRSsAKTLKNR | phosphorylation down-regulates | 20679343 | SIGNOR-167290 |
| CDK5/CDK5R1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251598 |
| CAMK2A | MAPT | Ser552 | VVRTPPKsPSSAKSR | phosphorylation down-regulates activity | 10090741 | SIGNOR-249316 |
| GSK3B | MAPT | – | phosphorylation down-regulates | 21443865 | SIGNOR-255486 | |
| CAMK2A | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 10090741 | SIGNOR-249315 |
| FYN | MAPT | Tyr18 | MEDHAGTyGLGDRKD | phosphorylation down-regulates | 14999081 | SIGNOR-123099 |
| PRKACA | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171066 |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-92607 |
| GSK3B | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 17078951 | SIGNOR-150360 |
| GSK3B | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-249350 |
| CDK5/CDK5R1 | MAPT | Ser713 | GAEIVYKsPVVSGDT | phosphorylation down-regulates activity | 12387894 | SIGNOR-251591 |
| DYRK1A | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 21215781 | SIGNOR-171030 |
| CDK5/CDK5R1 | MAPT | Ser552 | VVRTPPKsPSSAKSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251590 |
| CDK5 | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249326 |
| ALK | MAPT | – | phosphorylation up-regulates quantity | 33452442 | SIGNOR-279318 | |
| TTK | MAPT | – | phosphorylation up-regulates activity | 11257498 | SIGNOR-279132 | |
| CDK5 | MAPT | Ser235 | SPQDSPPsKASPAQD | phosphorylation down-regulates | 21215781 | SIGNOR-171018 |
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-251596 |
| MARK2 | MAPT | Ser355 | EADLPEPsEKQPAAA | phosphorylation down-regulates activity | 10090741 | SIGNOR-275436 |
| LRRK2 | MAPT | – | phosphorylation down-regulates | 22303461 | SIGNOR-195756 | |
| SGK1 | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates | 16982696 | SIGNOR-161288 |
| PHKG1 | MAPT | Ser669 | DFKDRVQsKIGSLDN | phosphorylation down-regulates activity | 8999860 | SIGNOR-250287 |
| PPP2R1A | MAPT | – | dephosphorylation down-regulates | 15525651 | SIGNOR-130136 | |
| GSK3B | MAPT | Ser713 | GAEIVYKsPVVSGDT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249345 |
| MAPK12 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 9199504 | SIGNOR-250087 |
| PP2B | MAPT | Ser721 | PVVSGDTsPRHLSNV | dephosphorylation up-regulates | 20308788 | SIGNOR-164667 |
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-251599 |
| PRKACA | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 9614189 | SIGNOR-250006 |
| CDK5/CDK5R1 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251594 |
| CDK5 | MAPT | Ser552 | VVRTPPKsPSSAKSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249319 |
| CSNK1D | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 14761950 | SIGNOR-121705 |
| CSNK1D | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates | 14761950 | SIGNOR-121709 |
| CHEK2 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171026 |
| PHKG1 | MAPT | Ser554 | RTPPKSPsSAKSRLQ | phosphorylation down-regulates activity | 8999860 | SIGNOR-250283 |
| GSK3B | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171042 |
| ALPL | MAPT | – | dephosphorylation down-regulates activity | 24646911 | SIGNOR-277097 | |
| CDK5/CDK5R1 | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251597 |
| GSK3B | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171046 |
| CDK5 | MAPT | Ser713 | GAEIVYKsPVVSGDT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249320 |
| GSK3A | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60651 |
| TTBK1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 16923168 | SIGNOR-148974 |
| AMPK | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates activity | 21204788 | SIGNOR-273930 |
| CDK5 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-249321 |
| PRKACA | MAPT | Ser726 | DTSPRHLsNVSSTGS | phosphorylation down-regulates activity | 12435421 | SIGNOR-250009 |
| MARK1 | MAPT | Ser637 | VDLSKVTsKCGSLGN | phosphorylation down-regulates activity | 10090741 | SIGNOR-250173 |
| MARK4 | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates activity | 21204788 | SIGNOR-273935 |
| EIF2AK2 | MAPT | – | phosphorylation up-regulates quantity | 32716602 | SIGNOR-279735 | |
| MAPK11 | MAPT | – | phosphorylation down-regulates activity | 9199504 | SIGNOR-279637 | |
| PRKACA | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60659 |
| p38 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171062 |
| GSK3B | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249352 |
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251588 |
| CAMK2A | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 10090741 | SIGNOR-249314 |
| TTBK1 | MAPT | Ser515 | SGDRSGYsSPGSPGT | phosphorylation down-regulates | 16923168 | SIGNOR-148966 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHKG1 | phosphorylation up-regulates → | MAPT PSer622 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250286 |
| DYRK1A | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171038 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249318 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer512 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-249353 |
| PRKAA1 | phosphorylation up-regulates → | MAPT PSer355 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275440 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250175 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation down-regulates ⊣ | MAPT | 12435421 | SIGNOR-250007 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer717 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249355 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-251601 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer515 | phosphorylation down-regulates ⊣ | MAPT | 9832145 | SIGNOR-249354 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249343 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer641 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171054 |
| MARK4 | phosphorylation up-regulates → | MAPT PSer420 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273936 |
| MAPK12 | phosphorylation up-regulates → | MAPT PSer637 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250085 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171050 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251592 |
| CSNK1D | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121717 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer516 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164659 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249327 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer579 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164663 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251595 |
| PKN1 | phosphorylation up-regulates → | MAPT PSer637 | phosphorylation down-regulates ⊣ | MAPT | 11104762 | SIGNOR-84958 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249348 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250172 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251600 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249346 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr529 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164675 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 17078951 | SIGNOR-150364 |
| AMPK | phosphorylation up-regulates → | MAPT PSer420 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273931 |
| MAPK1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249417 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249323 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer641 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250174 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer739 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148978 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251593 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249349 |
| MAPK12 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250084 |
| SYK | phosphorylation up-regulates → | MAPT PTyr18 | phosphorylation down-regulates ⊣ | MAPT | 18070606 | SIGNOR-159648 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249317 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249322 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249351 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 12435421 | SIGNOR-250008 |
| MAPK1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249416 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249344 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164651 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171022 |
| PHKG1 | phosphorylation up-regulates → | MAPT PSer602 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250285 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249325 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148970 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92603 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171058 |
| MAPK1 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249418 |
| CSNK1D | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121713 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 20679343 | SIGNOR-167294 |
| GSK3A | phosphorylation up-regulates → | MAPT PSer641 | phosphorylation down-regulates ⊣ | MAPT | 7706316 | SIGNOR-249342 |
| DYRK1A | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171034 |
| NUAK1 | phosphorylation up-regulates → | MAPT PSer673 | phosphorylation up-regulates → | MAPT | 27720485 | SIGNOR-279306 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164655 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251589 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr522 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164671 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60655 |
| MAPK12 | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250086 |
| MAPK12 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250088 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249347 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 20679343 | SIGNOR-167286 |
| AMPK | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273926 |
| PRKAA1 | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275439 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249324 |
| PHKG1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250284 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer235 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-251587 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer400 | phosphorylation down-regulates ⊣ | MAPT | 20679343 | SIGNOR-167290 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251598 |
| CAMK2A | phosphorylation up-regulates → | MAPT PSer552 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-249316 |
| CAMK2A | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-249315 |
| FYN | phosphorylation up-regulates → | MAPT PTyr18 | phosphorylation down-regulates ⊣ | MAPT | 14999081 | SIGNOR-123099 |
| PRKACA | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171066 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92607 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 17078951 | SIGNOR-150360 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249350 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer713 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251591 |
| DYRK1A | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171030 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer552 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251590 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249326 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer235 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171018 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251596 |
| MARK2 | phosphorylation up-regulates → | MAPT PSer355 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275436 |
| SGK1 | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 16982696 | SIGNOR-161288 |
| PHKG1 | phosphorylation up-regulates → | MAPT PSer669 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250287 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer713 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249345 |
| MAPK12 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250087 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer721 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164667 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251599 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 9614189 | SIGNOR-250006 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251594 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer552 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249319 |
| CSNK1D | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121705 |
| CSNK1D | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121709 |
| CHEK2 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171026 |
| PHKG1 | phosphorylation up-regulates → | MAPT PSer554 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250283 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171042 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251597 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171046 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer713 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249320 |
| GSK3A | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60651 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148974 |
| AMPK | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273930 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249321 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer726 | phosphorylation down-regulates ⊣ | MAPT | 12435421 | SIGNOR-250009 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer637 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250173 |
| MARK4 | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273935 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60659 |
| p38 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171062 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249352 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251588 |
| CAMK2A | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-249314 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer515 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148966 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250286 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171038 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249318 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249353 |
| PRKAA1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275440 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250175 |
| PRKACA | phosphorylation → down-regulates activity | MAPT | SIGNOR-250007 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249355 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251601 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249354 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249343 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171054 |
| MARK4 | phosphorylation → down-regulates activity | MAPT | SIGNOR-273936 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250085 |
| GSK3A | phosphorylation down-regulates | MAPT | SIGNOR-29364 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171050 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251592 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121717 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164659 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249327 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164663 |
| PINK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-279250 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251595 |
| PKN1 | phosphorylation down-regulates | MAPT | SIGNOR-84958 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249348 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250172 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251600 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249346 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164675 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-150364 |
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273931 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249417 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249323 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250174 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148978 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251593 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249349 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250084 |
| SYK | phosphorylation down-regulates | MAPT | SIGNOR-159648 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249317 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249322 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249351 |
| PRKACA | phosphorylation → down-regulates activity | MAPT | SIGNOR-250008 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249416 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249344 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-164651 |
| PTEN | dephosphorylation → up-regulates activity | MAPT | SIGNOR-277079 |
| MAPK13 | phosphorylation → down-regulates activity | MAPT | SIGNOR-278313 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-171022 |
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250285 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249325 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148970 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92603 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171058 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249418 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121713 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-167294 |
| GSK3A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249342 |
| MAPK14 | phosphorylation → up-regulates | MAPT | SIGNOR-166611 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171034 |
| NUAK1 | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279306 |
| MARK2 | phosphorylation → down-regulates quantity | MAPT | SIGNOR-280038 |
| CAMK2A | phosphorylation down-regulates | MAPT | SIGNOR-255490 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-164655 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251589 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164671 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-60655 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250086 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250088 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249347 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-167286 |
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273926 |
| PRKAA1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275439 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249324 |
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250284 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251587 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-167290 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251598 |
| CAMK2A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249316 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-255486 |
| CAMK2A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249315 |
| FYN | phosphorylation down-regulates | MAPT | SIGNOR-123099 |
| PRKACA | phosphorylation down-regulates | MAPT | SIGNOR-171066 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92607 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-150360 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249350 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251591 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171030 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251590 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249326 |
| ALK | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279318 |
| TTK | phosphorylation → up-regulates activity | MAPT | SIGNOR-279132 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-171018 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251596 |
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275436 |
| LRRK2 | phosphorylation down-regulates | MAPT | SIGNOR-195756 |
| SGK1 | phosphorylation down-regulates | MAPT | SIGNOR-161288 |
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250287 |
| PPP2R1A | dephosphorylation down-regulates | MAPT | SIGNOR-130136 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249345 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250087 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164667 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251599 |
| PRKACA | phosphorylation → down-regulates activity | MAPT | SIGNOR-250006 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251594 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249319 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121705 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121709 |
| CHEK2 | phosphorylation down-regulates | MAPT | SIGNOR-171026 |
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250283 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-171042 |
| ALPL | dephosphorylation → down-regulates activity | MAPT | SIGNOR-277097 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251597 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-171046 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249320 |
| GSK3A | phosphorylation down-regulates | MAPT | SIGNOR-60651 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148974 |
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273930 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249321 |
| PRKACA | phosphorylation → down-regulates activity | MAPT | SIGNOR-250009 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250173 |
| MARK4 | phosphorylation → down-regulates activity | MAPT | SIGNOR-273935 |
| EIF2AK2 | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279735 |
| MAPK11 | phosphorylation → down-regulates activity | MAPT | SIGNOR-279637 |
| PRKACA | phosphorylation down-regulates | MAPT | SIGNOR-60659 |
| p38 | phosphorylation down-regulates | MAPT | SIGNOR-171062 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249352 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251588 |
| CAMK2A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249314 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148966 |
