| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK2 | MAPT | Ser267 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275435 |
| MAPK3 | MAPT | Ser267 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275434 |
| PRKAA1 | MAPT | Ser267 | RVQSKIGsLDNITHV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275438 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MARK2 | phosphorylation up-regulates → | MAPT PSer267 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275435 |
| MAPK3 | phosphorylation up-regulates → | MAPT PSer267 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275434 |
| PRKAA1 | phosphorylation up-regulates → | MAPT PSer267 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275438 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275435 |
| MAPK3 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275434 |
| PRKAA1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275438 |