| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275442 |
| PRKCA | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275441 |
| PRKCI | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275446 |
| PRKCB | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275443 |
| PRKCG | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275445 |
| MARK2 | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275437 |
| PRKCZ | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275447 |
| PRKCE | MAPT | Ser324 | RHLSNVSsTGSIDMV | phosphorylation down-regulates activity | 10090741 | SIGNOR-275444 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275442 |
| PRKCA | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275441 |
| PRKCI | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275446 |
| PRKCB | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275443 |
| PRKCG | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275445 |
| MARK2 | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275437 |
| PRKCZ | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275447 |
| PRKCE | phosphorylation up-regulates → | MAPT PSer324 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275444 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCB | phosphorylation → down-regulates activity | MAPT | SIGNOR-275442 |
| PRKCA | phosphorylation → down-regulates activity | MAPT | SIGNOR-275441 |
| PRKCI | phosphorylation → down-regulates activity | MAPT | SIGNOR-275446 |
| PRKCB | phosphorylation → down-regulates activity | MAPT | SIGNOR-275443 |
| PRKCG | phosphorylation → down-regulates activity | MAPT | SIGNOR-275445 |
| MARK2 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275437 |
| PRKCZ | phosphorylation → down-regulates activity | MAPT | SIGNOR-275447 |
| PRKCE | phosphorylation → down-regulates activity | MAPT | SIGNOR-275444 |
