Entity Details

Name MAPT
ID P10636-5
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AMPKMAPTSer262NVKSKIGsTENLKHQphosphorylation
down-regulates activity		21204788SIGNOR-273928
MARK4MAPTThr231KKVAVVRtPPKSPSSphosphorylation
down-regulates activity		21204788SIGNOR-273932
MARK4MAPTSer262NVKSKIGsTENLKHQphosphorylation
down-regulates activity		21204788SIGNOR-273933
AMPKMAPTThr231KKVAVVRtPPKSPSSphosphorylation
down-regulates activity		21204788SIGNOR-273927
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AMPKphosphorylation
up-regulates
→
MAPT
PSer262		phosphorylation
down-regulates
⊣		MAPT21204788SIGNOR-273928
MARK4phosphorylation
up-regulates
→
MAPT
PThr231		phosphorylation
down-regulates
⊣		MAPT21204788SIGNOR-273932
MARK4phosphorylation
up-regulates
→
MAPT
PSer262		phosphorylation
down-regulates
⊣		MAPT21204788SIGNOR-273933
AMPKphosphorylation
up-regulates
→
MAPT
PThr231		phosphorylation
down-regulates
⊣		MAPT21204788SIGNOR-273927
Regulator Mechanism/Effect Target SIGNOR-ID
AMPKphosphorylation
→
down-regulates activity 		MAPTSIGNOR-273928
MARK4phosphorylation
→
down-regulates activity 		MAPTSIGNOR-273932
MARK4phosphorylation
→
down-regulates activity 		MAPTSIGNOR-273933
AMPKphosphorylation
→
down-regulates activity 		MAPTSIGNOR-273927