| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | MAPT | Thr231 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 21204788 | SIGNOR-273927 |
| MARK4 | MAPT | Thr231 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 21204788 | SIGNOR-273932 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | MAPT PThr231 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273927 |
| MARK4 | phosphorylation up-regulates → | MAPT PThr231 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273932 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273927 |
| MARK4 | phosphorylation → down-regulates activity | MAPT | SIGNOR-273932 |