| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates | 14761950 | SIGNOR-121709 |
| AMPK | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates activity | 21204788 | SIGNOR-273930 |
| MARK4 | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates activity | 21204788 | SIGNOR-273935 |
| GSK3B | MAPT | Ser396 | DDKKAKTsTRSSAKT | phosphorylation down-regulates | 20679343 | SIGNOR-167286 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121709 |
| AMPK | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273930 |
| MARK4 | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273935 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer396 | phosphorylation down-regulates ⊣ | MAPT | 20679343 | SIGNOR-167286 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121709 |
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273930 |
| MARK4 | phosphorylation → down-regulates activity | MAPT | SIGNOR-273935 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-167286 |
