| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | MAPT | Ser516 | GDRSGYSsPGSPGTP | dephosphorylation up-regulates | 20308788 | SIGNOR-164659 |
| GSK3B | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249352 |
| CDK5 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249327 |
| GSK3B | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates | 20308788 | SIGNOR-164651 |
| CDK5/CDK5R1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251598 |
| TTBK1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates | 16923168 | SIGNOR-148970 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer516 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164659 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249352 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249327 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164651 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251598 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148970 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164659 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249352 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249327 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-164651 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251598 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148970 |
