| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249348 |
| CDK5/CDK5R1 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251594 |
| DYRK1A | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates | 21215781 | SIGNOR-171038 |
| PP2B | MAPT | Thr529 | TPGSRSRtPSLPTPP | dephosphorylation up-regulates | 20308788 | SIGNOR-164675 |
| CDK5 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-249323 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249348 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251594 |
| DYRK1A | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171038 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr529 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164675 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249323 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249348 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251594 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171038 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164675 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249323 |
