Entity Details

Name CDK5/CDK5R1_Thr534
ID P10636
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK5/CDK5R1MAPTThr534SRTPSLPtPPTREPKphosphorylation
down-regulates activity		12387894SIGNOR-251595
GSK3BMAPTThr534SRTPSLPtPPTREPKphosphorylation
down-regulates activity		12387894SIGNOR-249349
GSK3BMAPTThr534SRTPSLPtPPTREPKphosphorylation
down-regulates		17078951SIGNOR-150364
CDK5MAPTThr534SRTPSLPtPPTREPKphosphorylation
down-regulates activity		12387894SIGNOR-249324
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK5/CDK5R1phosphorylation
up-regulates
→
MAPT
PThr534		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-251595
GSK3Bphosphorylation
up-regulates
→
MAPT
PThr534		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-249349
GSK3Bphosphorylation
up-regulates
→
MAPT
PThr534		phosphorylation
down-regulates
⊣		MAPT17078951SIGNOR-150364
CDK5phosphorylation
up-regulates
→
MAPT
PThr534		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-249324
Regulator Mechanism/Effect Target SIGNOR-ID
CDK5/CDK5R1phosphorylation
→
down-regulates activity 		MAPTSIGNOR-251595
GSK3Bphosphorylation
→
down-regulates activity 		MAPTSIGNOR-249349
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates 		MAPTSIGNOR-150364
CDK5phosphorylation
→
down-regulates activity 		MAPTSIGNOR-249324