| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | MAPT | Ser721 | PVVSGDTsPRHLSNV | dephosphorylation up-regulates | 20308788 | SIGNOR-164667 |
| CDK5 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-249321 |
| CDK5/CDK5R1 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-251592 |
| GSK3B | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-249346 |
| MAPK1 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 10737616 | SIGNOR-249418 |
| CSNK1D | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 14761950 | SIGNOR-121713 |
| GSK3B | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 20679343 | SIGNOR-167294 |
| DYRK1A | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates | 21215781 | SIGNOR-171034 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer721 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164667 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249321 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251592 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249346 |
| MAPK1 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249418 |
| CSNK1D | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121713 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 20679343 | SIGNOR-167294 |
| DYRK1A | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171034 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164667 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249321 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251592 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249346 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249418 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121713 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-167294 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171034 |
