| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | MAPT | Ser515 | SGDRSGYsSPGSPGT | phosphorylation down-regulates activity | 9832145 | SIGNOR-249354 |
| TTBK1 | MAPT | Ser515 | SGDRSGYsSPGSPGT | phosphorylation down-regulates | 16923168 | SIGNOR-148966 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | MAPT PSer515 | phosphorylation down-regulates ⊣ | MAPT | 9832145 | SIGNOR-249354 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer515 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148966 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249354 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148966 |
