Entity Details

Name MAPK12_Thr498
ID P10636
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BMAPTThr498KTPPAPKtPPSSGEPphosphorylation
down-regulates activity		12387894SIGNOR-249351
MAPK12MAPTThr498KTPPAPKtPPSSGEPphosphorylation
down-regulates activity		9199504SIGNOR-250086
CDK5MAPTThr498KTPPAPKtPPSSGEPphosphorylation
down-regulates activity		12387894SIGNOR-249326
CDK5/CDK5R1MAPTThr498KTPPAPKtPPSSGEPphosphorylation
down-regulates activity		12387894SIGNOR-251597
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
MAPT
PThr498		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-249351
MAPK12phosphorylation
up-regulates
→
MAPT
PThr498		phosphorylation
down-regulates
⊣		MAPT9199504SIGNOR-250086
CDK5phosphorylation
up-regulates
→
MAPT
PThr498		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-249326
CDK5/CDK5R1phosphorylation
up-regulates
→
MAPT
PThr498		phosphorylation
down-regulates
⊣		MAPT12387894SIGNOR-251597
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
→
down-regulates activity 		MAPTSIGNOR-249351
MAPK12phosphorylation
→
down-regulates activity 		MAPTSIGNOR-250086
CDK5phosphorylation
→
down-regulates activity 		MAPTSIGNOR-249326
CDK5/CDK5R1phosphorylation
→
down-regulates activity 		MAPTSIGNOR-251597