| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251588 |
| MAPK12 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 9199504 | SIGNOR-250084 |
| GSK3B | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 17078951 | SIGNOR-150360 |
| DYRK1A | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 21215781 | SIGNOR-171030 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-92603 |
| CSNK1D | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 14761950 | SIGNOR-121705 |
| TTBK1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 16923168 | SIGNOR-148974 |
| CDK5 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249317 |
| GSK3B | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-249343 |
| MAPK1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 10737616 | SIGNOR-249416 |
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-251599 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251588 |
| MAPK12 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250084 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 17078951 | SIGNOR-150360 |
| DYRK1A | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171030 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92603 |
| CSNK1D | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121705 |
| TTBK1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 16923168 | SIGNOR-148974 |
| CDK5 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249317 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249343 |
| MAPK1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249416 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251599 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251588 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250084 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-150360 |
| DYRK1A | phosphorylation down-regulates | MAPT | SIGNOR-171030 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92603 |
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121705 |
| TTBK1 | phosphorylation down-regulates | MAPT | SIGNOR-148974 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249317 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249343 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249416 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251599 |
