| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 14761950 | SIGNOR-121717 |
| MAPK1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 10737616 | SIGNOR-249417 |
| PP2B | MAPT | Thr522 | SSPGSPGtPGSRSRT | dephosphorylation up-regulates | 20308788 | SIGNOR-164671 |
| MAPK12 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 9199504 | SIGNOR-250087 |
| GSK3B | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249347 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-251593 |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-249322 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-251600 |
| GSK3B | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 20308788 | SIGNOR-164655 |
| CDK5 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-92607 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 14761950 | SIGNOR-121717 |
| MAPK1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 10737616 | SIGNOR-249417 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PThr522 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164671 |
| MAPK12 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250087 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249347 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251593 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249322 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251600 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164655 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-92607 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation down-regulates | MAPT | SIGNOR-121717 |
| MAPK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249417 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164671 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250087 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249347 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251593 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249322 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251600 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-164655 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-92607 |
