| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60659 |
| CAMK2A | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 10090741 | SIGNOR-249314 |
| PHKG1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 8999860 | SIGNOR-250284 |
| GSK3B | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60655 |
| CHEK2 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171026 |
| GSK3B | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171042 |
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 21215781 | SIGNOR-171050 |
| MARK1 | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 10090741 | SIGNOR-250172 |
| PRKACA | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates activity | 12435421 | SIGNOR-250008 |
| PP2B | MAPT | Ser579 | NVKSKIGsTENLKHQ | dephosphorylation up-regulates | 20308788 | SIGNOR-164663 |
| GSK3A | MAPT | Ser579 | NVKSKIGsTENLKHQ | phosphorylation down-regulates | 9771888 | SIGNOR-60651 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60659 |
| CAMK2A | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-249314 |
| PHKG1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 8999860 | SIGNOR-250284 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60655 |
| CHEK2 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171026 |
| GSK3B | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171042 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171050 |
| MARK1 | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-250172 |
| PRKACA | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 12435421 | SIGNOR-250008 |
| PP2B | dephosphorylation down-regulates ⊣ | MAPT PSer579 | dephosphorylation down-regulates ⊣ | MAPT | 20308788 | SIGNOR-164663 |
| GSK3A | phosphorylation up-regulates → | MAPT PSer579 | phosphorylation down-regulates ⊣ | MAPT | 9771888 | SIGNOR-60651 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation down-regulates | MAPT | SIGNOR-60659 |
| CAMK2A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249314 |
| PHKG1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250284 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-60655 |
| CHEK2 | phosphorylation down-regulates | MAPT | SIGNOR-171026 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-171042 |
| MARK1 | phosphorylation down-regulates | MAPT | SIGNOR-171050 |
| MARK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250172 |
| PRKACA | phosphorylation → down-regulates activity | MAPT | SIGNOR-250008 |
| PP2B | dephosphorylation → up-regulates | MAPT | SIGNOR-164663 |
| GSK3A | phosphorylation down-regulates | MAPT | SIGNOR-60651 |
