| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-251596 |
| MAPK12 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 9199504 | SIGNOR-250088 |
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-251601 |
| GSK3B | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-249350 |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-249325 |
| CAMK2A | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 10090741 | SIGNOR-249315 |
| PRKACA | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171066 |
| p38 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171062 |
| CDK5 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171022 |
| GSK3B | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-171046 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251596 |
| MAPK12 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 9199504 | SIGNOR-250088 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-251601 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249350 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-249325 |
| CAMK2A | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-249315 |
| PRKACA | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171066 |
| p38 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171062 |
| CDK5 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171022 |
| GSK3B | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-171046 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251596 |
| MAPK12 | phosphorylation → down-regulates activity | MAPT | SIGNOR-250088 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251601 |
| GSK3B | phosphorylation → down-regulates activity | MAPT | SIGNOR-249350 |
| CDK5 | phosphorylation → down-regulates activity | MAPT | SIGNOR-249325 |
| CAMK2A | phosphorylation → down-regulates activity | MAPT | SIGNOR-249315 |
| PRKACA | phosphorylation down-regulates | MAPT | SIGNOR-171066 |
| p38 | phosphorylation down-regulates | MAPT | SIGNOR-171062 |
| CDK5 | phosphorylation down-regulates | MAPT | SIGNOR-171022 |
| GSK3B | phosphorylation down-regulates | MAPT | SIGNOR-171046 |
