| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates | 16982696 | SIGNOR-161288 |
| PRKAA1 | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates activity | 10090741 | SIGNOR-275439 |
| AMPK | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates activity | 21204788 | SIGNOR-273926 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 16982696 | SIGNOR-161288 |
| PRKAA1 | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 10090741 | SIGNOR-275439 |
| AMPK | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 21204788 | SIGNOR-273926 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation![]() down-regulates | MAPT | SIGNOR-161288 |
| PRKAA1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-275439 |
| AMPK | phosphorylation → down-regulates activity | MAPT | SIGNOR-273926 |