Entity Details

Name KIT
ID P10721
Role kinase
Enzymatic Domains
Ig-like C2-type 1 27-112
Ig-like C2-type 2 121-205
Ig-like C2-type 3 212-308
Ig-like C2-type 4 317-410
Ig-like C2-type 5 413-507
Protein kinase 589-937
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
KITKITTyr703DHAEAALyKNLLHSKphosphorylation
up-regulates
10377264SIGNOR-68643
KITKITTyr936SESTNHIySNLANCSphosphorylation
up-regulates
10377264SIGNOR-68647
KITKITTyr568EEINGNNyVYIDPTQphosphorylation
up-regulates activity
12824176SIGNOR-102633
KITKITTyr570INGNNYVyIDPTQLPphosphorylation
up-regulates activity
12824176SIGNOR-102637
KITKITTyr823DIKNDSNyVVKGNARphosphorylation
up-regulates activity
12824176SIGNOR-102641
KITCBLphosphorylation
up-regulates activity
15315962SIGNOR-279199
KITCTNNB1phosphorylation
up-regulates activity
17949810SIGNOR-278361
KITPHBTyr259SRSRNITyLPAGQSVphosphorylation
up-regulates activity
32169072SIGNOR-278362
KITSTAT1Tyr701DGPKGTGyIKTELISphosphorylation
up-regulates activity
21135090SIGNOR-251365
KITPTPN11phosphorylation
up-regulates activity
22806893SIGNOR-256140
KITSLATyr120SETKKGFySLSVRHRphosphorylation
down-regulates activity
24284075SIGNOR-263140
KITSLATyr258KKSISLMyGGSKRKSphosphorylation
down-regulates activity
24284075SIGNOR-263141
KITSLATyr273SFFSSPPyFEDphosphorylation
down-regulates activity
24284075SIGNOR-263142
KITSTAP1phosphorylation
up-regulates activity
10679268SIGNOR-261820
KITPI3Kphosphorylation
up-regulates activity
15526160SIGNOR-254949
KITSRC_kinase_familyphosphorylation
up-regulates
15526160SIGNOR-254995
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
KITphosphorylation
up-regulates
KIT
PTyr703
phosphorylation
up-regulates
KIT10377264SIGNOR-68643
KITphosphorylation
up-regulates
KIT
PTyr936
phosphorylation
up-regulates
KIT10377264SIGNOR-68647
KITphosphorylation
up-regulates
KIT
PTyr568
phosphorylation
up-regulates
KIT12824176SIGNOR-102633
KITphosphorylation
up-regulates
KIT
PTyr570
phosphorylation
up-regulates
KIT12824176SIGNOR-102637
KITphosphorylation
up-regulates
KIT
PTyr823
phosphorylation
up-regulates
KIT12824176SIGNOR-102641
KITphosphorylation
up-regulates
PHB
PTyr259
phosphorylation
up-regulates
PHB32169072SIGNOR-278362
KITphosphorylation
up-regulates
STAT1
PTyr701
phosphorylation
up-regulates
STAT121135090SIGNOR-251365
KITphosphorylation
up-regulates
SLA
PTyr120
phosphorylation
down-regulates
SLA24284075SIGNOR-263140
KITphosphorylation
up-regulates
SLA
PTyr258
phosphorylation
down-regulates
SLA24284075SIGNOR-263141
KITphosphorylation
up-regulates
SLA
PTyr273
phosphorylation
down-regulates
SLA24284075SIGNOR-263142
Regulator Mechanism/Effect Target SIGNOR-ID
KITphosphorylation

up-regulates
KITSIGNOR-68643
KITphosphorylation

up-regulates
KITSIGNOR-68647
KITphosphorylation

up-regulates activity
KITSIGNOR-102633
KITphosphorylation

up-regulates activity
KITSIGNOR-102637
KITphosphorylation

up-regulates activity
KITSIGNOR-102641
KITphosphorylation

up-regulates activity
CBLSIGNOR-279199
KITphosphorylation

up-regulates activity
CTNNB1SIGNOR-278361
KITphosphorylation

up-regulates activity
PHBSIGNOR-278362
KITphosphorylation

up-regulates activity
STAT1SIGNOR-251365
KITphosphorylation

up-regulates activity
PTPN11SIGNOR-256140
KITphosphorylation

down-regulates activity
SLASIGNOR-263140
KITphosphorylation

down-regulates activity
SLASIGNOR-263141
KITphosphorylation

down-regulates activity
SLASIGNOR-263142
KITphosphorylation

up-regulates activity
STAP1SIGNOR-261820
KITphosphorylation

up-regulates activity
PI3KSIGNOR-254949
KITphosphorylation

up-regulates
SRC_kinase_familySIGNOR-254995