| Name | KIT |
| ID | P10721 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 27-112
Ig-like C2-type 2 121-205
Ig-like C2-type 3 212-308
Ig-like C2-type 4 317-410
Ig-like C2-type 5 413-507
Protein kinase 589-937 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | KIT | Ser741 | TKADKRRsVRIGSYI | phosphorylation down-regulates activity | 7539802 | SIGNOR-248898 |
| CHEK2 | KIT | – | phosphorylation up-regulates | 22558186 | SIGNOR-197281 | |
| PRKCA | KIT | Ser821 | ARDIKNDsNYVVKGN | phosphorylation down-regulates activity | 7539802 | SIGNOR-248897 |
| PRKCA | KIT | Ser959 | DHSVRINsVGSTASS | phosphorylation down-regulates activity | 7539802 | SIGNOR-248900 |
| KIT | KIT | Tyr570 | INGNNYVyIDPTQLP | phosphorylation up-regulates activity | 12824176 | SIGNOR-102637 |
| PRKCA | KIT | Ser746 | RRSVRIGsYIERDVT | phosphorylation down-regulates | 7539802 | SIGNOR-28605 |
| PTPRG | KIT | Tyr730 | DMKPGVSyVVPTKAD | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254710 |
| PRKCA | KIT | Ser741 | TKADKRRsVRIGSYI | phosphorylation down-regulates | 7539802 | SIGNOR-28601 |
| KIT | KIT | Tyr703 | DHAEAALyKNLLHSK | phosphorylation up-regulates | 10377264 | SIGNOR-68643 |
| PTPRG | KIT | Tyr703 | DHAEAALyKNLLHSK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254709 |
| KIT | KIT | Tyr823 | DIKNDSNyVVKGNAR | phosphorylation up-regulates activity | 12824176 | SIGNOR-102641 |
| SRC | KIT | Tyr900 | EHAPAEMyDIMKTCW | phosphorylation up-regulates activity | 12878163 | SIGNOR-103999 |
| KIT | KIT | Tyr936 | SESTNHIySNLANCS | phosphorylation up-regulates | 10377264 | SIGNOR-68647 |
| KIT | KIT | Tyr568 | EEINGNNyVYIDPTQ | phosphorylation up-regulates activity | 12824176 | SIGNOR-102633 |
| PRKCA | KIT | Ser746 | RRSVRIGsYIERDVT | phosphorylation down-regulates activity | 7539802 | SIGNOR-248899 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | KIT PSer741 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-248898 |
| PRKCA | phosphorylation up-regulates → | KIT PSer821 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-248897 |
| PRKCA | phosphorylation up-regulates → | KIT PSer959 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-248900 |
| KIT | phosphorylation up-regulates → | KIT PTyr570 | phosphorylation up-regulates → | KIT | 12824176 | SIGNOR-102637 |
| PRKCA | phosphorylation up-regulates → | KIT PSer746 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-28605 |
| PTPRG | dephosphorylation down-regulates ⊣ | KIT PTyr730 | dephosphorylation up-regulates → | KIT | 25624455 | SIGNOR-254710 |
| PRKCA | phosphorylation up-regulates → | KIT PSer741 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-28601 |
| KIT | phosphorylation up-regulates → | KIT PTyr703 | phosphorylation up-regulates → | KIT | 10377264 | SIGNOR-68643 |
| PTPRG | dephosphorylation down-regulates ⊣ | KIT PTyr703 | dephosphorylation up-regulates → | KIT | 25624455 | SIGNOR-254709 |
| KIT | phosphorylation up-regulates → | KIT PTyr823 | phosphorylation up-regulates → | KIT | 12824176 | SIGNOR-102641 |
| SRC | phosphorylation up-regulates → | KIT PTyr900 | phosphorylation up-regulates → | KIT | 12878163 | SIGNOR-103999 |
| KIT | phosphorylation up-regulates → | KIT PTyr936 | phosphorylation up-regulates → | KIT | 10377264 | SIGNOR-68647 |
| KIT | phosphorylation up-regulates → | KIT PTyr568 | phosphorylation up-regulates → | KIT | 12824176 | SIGNOR-102633 |
| PRKCA | phosphorylation up-regulates → | KIT PSer746 | phosphorylation down-regulates ⊣ | KIT | 7539802 | SIGNOR-248899 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → down-regulates activity | KIT | SIGNOR-248898 |
| CHEK2 | phosphorylation → up-regulates | KIT | SIGNOR-197281 |
| PRKCA | phosphorylation → down-regulates activity | KIT | SIGNOR-248897 |
| PRKCA | phosphorylation → down-regulates activity | KIT | SIGNOR-248900 |
| KIT | phosphorylation → up-regulates activity | KIT | SIGNOR-102637 |
| PRKCA | phosphorylation down-regulates | KIT | SIGNOR-28605 |
| PTPRG | dephosphorylation → down-regulates activity | KIT | SIGNOR-254710 |
| PRKCA | phosphorylation down-regulates | KIT | SIGNOR-28601 |
| KIT | phosphorylation → up-regulates | KIT | SIGNOR-68643 |
| PTPRG | dephosphorylation → down-regulates activity | KIT | SIGNOR-254709 |
| KIT | phosphorylation → up-regulates activity | KIT | SIGNOR-102641 |
| SRC | phosphorylation → up-regulates activity | KIT | SIGNOR-103999 |
| KIT | phosphorylation → up-regulates | KIT | SIGNOR-68647 |
| KIT | phosphorylation → up-regulates activity | KIT | SIGNOR-102633 |
| PRKCA | phosphorylation → down-regulates activity | KIT | SIGNOR-248899 |