| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | KIT | Tyr703 | DHAEAALyKNLLHSK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254709 |
| KIT | KIT | Tyr703 | DHAEAALyKNLLHSK | phosphorylation up-regulates | 10377264 | SIGNOR-68643 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | KIT PTyr703 | dephosphorylation up-regulates → | KIT | 25624455 | SIGNOR-254709 |
| KIT | phosphorylation up-regulates → | KIT PTyr703 | phosphorylation up-regulates → | KIT | 10377264 | SIGNOR-68643 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → down-regulates activity | KIT | SIGNOR-254709 |
| KIT | phosphorylation → up-regulates | KIT | SIGNOR-68643 |
