| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates activity | 8992971 | SIGNOR-251336 |
| LCK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 8992971 | SIGNOR-45524 |
| ITK | CD28 | Tyr218 | PPRDFAAyRS | phosphorylation up-regulates activity | 8992971 | SIGNOR-251337 |
| ITK | CD28 | Tyr206 | PGPTRKHyQPYAPPR | phosphorylation up-regulates activity | 8992971 | SIGNOR-251334 |
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 22936936 | SIGNOR-198751 |
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 22936936 | SIGNOR-198747 |
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 8992971 | SIGNOR-45516 |
| ITK | CD28 | Tyr218 | PPRDFAAyRS | phosphorylation up-regulates | 8992971 | SIGNOR-45520 |
| ITK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 8992971 | SIGNOR-45512 |
| LCK | CD28 | Tyr191 | SRLLHSDyMNMTPRR | phosphorylation up-regulates | 22936936 | SIGNOR-198755 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251336 |
| LCK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45524 |
| ITK | phosphorylation up-regulates → | CD28 PTyr218 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251337 |
| ITK | phosphorylation up-regulates → | CD28 PTyr206 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-251334 |
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198751 |
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198747 |
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45516 |
| ITK | phosphorylation up-regulates → | CD28 PTyr218 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45520 |
| ITK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45512 |
| LCK | phosphorylation up-regulates → | CD28 PTyr191 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198755 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251336 |
| LCK | phosphorylation → up-regulates | CD28 | SIGNOR-45524 |
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251337 |
| ITK | phosphorylation → up-regulates activity | CD28 | SIGNOR-251334 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-198751 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-198747 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45516 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45520 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45512 |
| LCK | phosphorylation → up-regulates | CD28 | SIGNOR-198755 |
