| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 22936936 | SIGNOR-198751 |
| ITK | CD28 | Tyr209 | TRKHYQPyAPPRDFA | phosphorylation up-regulates | 8992971 | SIGNOR-45516 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 22936936 | SIGNOR-198751 |
| ITK | phosphorylation up-regulates → | CD28 PTyr209 | phosphorylation up-regulates → | CD28 | 8992971 | SIGNOR-45516 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-198751 |
| ITK | phosphorylation → up-regulates | CD28 | SIGNOR-45516 |
