Entity Details

Name THRB
ID P10828
Role substrate
Enzymatic Domains
NR LBD 217-461
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1THRBSer142IQKNLHPsYSCKYEGphosphorylation
down-regulates activity		12809513SIGNOR-102216
GbetaTHRB–phosphorylation
down-regulates activity		12809513SIGNOR-270016
MAPK3THRBSer142IQKNLHPsYSCKYEGphosphorylation
down-regulates activity		12809513SIGNOR-102224
ERK1/2THRB–phosphorylation
down-regulates activity		12809513SIGNOR-270143
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
THRB
PSer142		phosphorylation
down-regulates
⊣		THRB12809513SIGNOR-102216
MAPK3phosphorylation
up-regulates
→
THRB
PSer142		phosphorylation
down-regulates
⊣		THRB12809513SIGNOR-102224
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
→
down-regulates activity 		THRBSIGNOR-102216
Gbetaphosphorylation
→
down-regulates activity 		THRBSIGNOR-270016
MAPK3phosphorylation
→
down-regulates activity 		THRBSIGNOR-102224
ERK1/2phosphorylation
→
down-regulates activity 		THRBSIGNOR-270143