| Name | GHR |
| ID | P10912 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 151-254 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248418 |
| PTPN9 | GHR | – | dephosphorylation down-regulates | 12907755 | SIGNOR-104577 | |
| PTPN1 | GHR | Tyr487 | SLSNIDFyAQVSDIT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248419 |
| EPHA4 | GHR | – | phosphorylation up-regulates activity | 28686668 | SIGNOR-279461 | |
| JAK2 | GHR | – | phosphorylation up-regulates activity | 23071812 | SIGNOR-279198 | |
| DUSP7 | GHR | – | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248726 | |
| PTPN9 | GHR | – | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248505 | |
| PTPN2 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248391 |
| PTPRH | GHR | – | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248802 | |
| PTPN3 | GHR | Tyr534 | NFLMDNAyFCEADAK | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248459 |
| PTPRB | GHR | – | dephosphorylation down-regulates | 12907755 | SIGNOR-104580 | |
| PTPN2 | GHR | Tyr487 | SLSNIDFyAQVSDIT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248392 |
| PTPN2 | GHR | Tyr566 | SLNQEDIyITTESLT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248394 |
| PTPN1 | GHR | Tyr534 | NFLMDNAyFCEADAK | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248420 |
| DUSP7 | GHR | – | dephosphorylation down-regulates | 12907755 | SIGNOR-104545 | |
| PTPN1 | GHR | Tyr566 | SLNQEDIyITTESLT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248421 |
| PTPN2 | GHR | Tyr534 | NFLMDNAyFCEADAK | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248393 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248418 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr487 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248419 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248391 |
| PTPN3 | dephosphorylation down-regulates ⊣ | GHR PTyr534 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248459 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr487 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248392 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr566 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248394 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr534 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248420 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr566 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248421 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr534 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248393 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248418 |
| PTPN9 | dephosphorylation down-regulates | GHR | SIGNOR-104577 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248419 |
| EPHA4 | phosphorylation → up-regulates activity | GHR | SIGNOR-279461 |
| JAK2 | phosphorylation → up-regulates activity | GHR | SIGNOR-279198 |
| DUSP7 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248726 |
| PTPN9 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248505 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248391 |
| PTPRH | dephosphorylation → down-regulates activity | GHR | SIGNOR-248802 |
| PTPN3 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248459 |
| PTPRB | dephosphorylation down-regulates | GHR | SIGNOR-104580 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248392 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248394 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248420 |
| DUSP7 | dephosphorylation down-regulates | GHR | SIGNOR-104545 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248421 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248393 |