| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248391 |
| PTPN1 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248418 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248391 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248418 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248391 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248418 |