| Name | BCR |
| ID | P11274 |
| Role | substrate |
| Enzymatic Domains |
DH 498-691 PROSITE-ProRule
PH 708-866 PROSITE-ProRule
C2 893-1020 PROSITE-ProRule
Rho-GAP 1054-1248 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | BCR | Tyr246 | SCGVDGDyEDAELNP | phosphorylation down-regulates | 8955135 | SIGNOR-45330 |
| BCR-ABL | BCR | Tyr360 | VSPSPTTyRMFRDKS | phosphorylation down-regulates | 8622703 | SIGNOR-40619 |
| BCR-ABL | BCR | Tyr328 | YSPRSFEdCGGGYTP | phosphorylation down-regulates activity | 9467953 | SIGNOR-260829 |
| BCR-ABL | BCR | Tyr360 | VSPSPTTyRMFRDKS | phosphorylation down-regulates activity | 8622703 | SIGNOR-262530 |
| FES | BCR | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation down-regulates activity | 8955135 | SIGNOR-251136 |
| FES | BCR | Tyr246 | SCGVDGDyEDAELNP | phosphorylation down-regulates activity | 8955135 | SIGNOR-251137 |
| PTPN1 | BCR | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56818 | |
| BCR-ABL | BCR | Tyr283 | YQPYQSIyVGGMMEG | phosphorylation down-regulates | 8622703 | SIGNOR-40615 |
| BCR-ABL | BCR | Tyr177 | ADAEKPFyVNVEFHH | phosphorylation down-regulates activity | 8622703 | SIGNOR-40611 |
| FES | BCR | Tyr283 | YQPYQSIyVGGMMEG | phosphorylation down-regulates | 8955135 | SIGNOR-45343 |
| FES | BCR | Tyr279 | PPLEYQPyQSIYVGG | phosphorylation down-regulates | 8955135 | SIGNOR-45334 |
| BCR-ABL | BCR | Tyr360 | YSPRSFEdCGGGYTP | phosphorylation down-regulates activity | 9467953 | SIGNOR-260828 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FES | phosphorylation up-regulates → | BCR PTyr246 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45330 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40619 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr328 | phosphorylation down-regulates ⊣ | BCR | 9467953 | SIGNOR-260829 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-262530 |
| FES | phosphorylation up-regulates → | BCR PTyr177 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-251136 |
| FES | phosphorylation up-regulates → | BCR PTyr246 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-251137 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr283 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40615 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr177 | phosphorylation down-regulates ⊣ | BCR | 8622703 | SIGNOR-40611 |
| FES | phosphorylation up-regulates → | BCR PTyr283 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45343 |
| FES | phosphorylation up-regulates → | BCR PTyr279 | phosphorylation down-regulates ⊣ | BCR | 8955135 | SIGNOR-45334 |
| BCR-ABL | phosphorylation up-regulates → | BCR PTyr360 | phosphorylation down-regulates ⊣ | BCR | 9467953 | SIGNOR-260828 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FES | phosphorylation down-regulates | BCR | SIGNOR-45330 |
| BCR-ABL | phosphorylation down-regulates | BCR | SIGNOR-40619 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-260829 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-262530 |
| FES | phosphorylation → down-regulates activity | BCR | SIGNOR-251136 |
| FES | phosphorylation → down-regulates activity | BCR | SIGNOR-251137 |
| PTPN1 | dephosphorylation down-regulates | BCR | SIGNOR-56818 |
| BCR-ABL | phosphorylation down-regulates | BCR | SIGNOR-40615 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-40611 |
| FES | phosphorylation down-regulates | BCR | SIGNOR-45343 |
| FES | phosphorylation down-regulates | BCR | SIGNOR-45334 |
| BCR-ABL | phosphorylation → down-regulates activity | BCR | SIGNOR-260828 |