Entity Details

Name ERG
ID P11308
Role substrate
Enzymatic Domains
PNT 113-199
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BERGThr180KDDFQRLtPSYNADIphosphorylation
down-regulates quantity by destabilization		32871104SIGNOR-277528
CSNK1A1ERGSer39EMTASSSsDYGQTSKphosphorylation
down-regulates quantity by destabilization		26344095SIGNOR-276935
CSNK1DERG–phosphorylation
down-regulates activity		26344095SIGNOR-280234
CSNK1A1ERGSer38TEMTASSsSDYGQTSphosphorylation
down-regulates quantity by destabilization		26344095SIGNOR-276936
WEE1ERGTyr183FQRLTPSyNADILLSphosphorylation
down-regulates quantity by destabilization		32871104SIGNOR-277529
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
ERG
PThr180		phosphorylation
down-regulates
⊣		ERG32871104SIGNOR-277528
CSNK1A1phosphorylation
up-regulates
→
ERG
PSer39		phosphorylation
down-regulates
⊣		ERG26344095SIGNOR-276935
CSNK1A1phosphorylation
up-regulates
→
ERG
PSer38		phosphorylation
down-regulates
⊣		ERG26344095SIGNOR-276936
WEE1phosphorylation
up-regulates
→
ERG
PTyr183		phosphorylation
down-regulates
⊣		ERG32871104SIGNOR-277529
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERGSIGNOR-277528
CSNK1A1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERGSIGNOR-276935
CSNK1Dphosphorylation
→
down-regulates activity 		ERGSIGNOR-280234
CSNK1A1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERGSIGNOR-276936
WEE1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERGSIGNOR-277529