Entity Details

Name TOP1
ID P11387
Role substrate
Enzymatic Domains
Topo IB-type catalytic 432-765
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKDCTOP1Ser10GDHLHNDsQIEADFRphosphorylation
down-regulates quantity by destabilization		28415827SIGNOR-277352
ABL1TOP1Tyr268AKMLDHEyTTKEIFRphosphorylation
up-regulates activity		15448168SIGNOR-260775
PRKCATOP1Ser21ADFRLNDsHKHKDKHphosphorylation
up-regulates activity		18408216SIGNOR-276154
CDK1TOP1Ser112
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EKENGFSsPPQIKDEphosphorylation
up-regulates activity		18408216SIGNOR-276156
CDK1TOP1Ser394
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SKDAKVPsPPPGHKWphosphorylation
up-regulates activity		18408216SIGNOR-276157
CSNK2A1TOP1Ser10GDHLHNDsQIEADFRphosphorylation
up-regulates activity		18408216SIGNOR-276155
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKDCphosphorylation
up-regulates
→
TOP1
PSer10		phosphorylation
down-regulates
⊣		TOP128415827SIGNOR-277352
ABL1phosphorylation
up-regulates
→
TOP1
PTyr268		phosphorylation
up-regulates
→		TOP115448168SIGNOR-260775
PRKCAphosphorylation
up-regulates
→
TOP1
PSer21		phosphorylation
up-regulates
→		TOP118408216SIGNOR-276154
CDK1phosphorylation
up-regulates
→
TOP1
PSer112		phosphorylation
up-regulates
→		TOP118408216SIGNOR-276156
CDK1phosphorylation
up-regulates
→
TOP1
PSer394		phosphorylation
up-regulates
→		TOP118408216SIGNOR-276157
CSNK2A1phosphorylation
up-regulates
→
TOP1
PSer10		phosphorylation
up-regulates
→		TOP118408216SIGNOR-276155
Regulator Mechanism/Effect Target SIGNOR-ID
PRKDCphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		TOP1SIGNOR-277352
ABL1phosphorylation
→
up-regulates activity 		TOP1SIGNOR-260775
PRKCAphosphorylation
→
up-regulates activity 		TOP1SIGNOR-276154
CDK1phosphorylation
→
up-regulates activity 		TOP1SIGNOR-276156
CDK1phosphorylation
→
up-regulates activity 		TOP1SIGNOR-276157
CSNK2A1phosphorylation
→
up-regulates activity 		TOP1SIGNOR-276155