| Name | CDK4 |
| ID | P11802 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 6-295 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation down-regulates quantity by destabilization | 30881282 | SIGNOR-280214 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates | 19114991 | SIGNOR-182983 |
| CDK4 | RBL1 | Ser650 | SVHERYSsPTAGSAK | phosphorylation up-regulates activity | 12006580 | SIGNOR-250763 |
| CDK4 | FOXM1 | Thr620 | SKSVLPRtPESWRLT | phosphorylation up-regulates | 22094256 | SIGNOR-177259 |
| CDK4 | RB1 | Ser811 | IYISPLKsPYKISEG | phosphorylation down-regulates | 15809340 | SIGNOR-135185 |
| CDK4 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | phosphorylation unknown | 15241418 | SIGNOR-250767 |
| CDK4 | SMAD3 | Thr8 | MSSILPFtPPIVKRL | phosphorylation down-regulates activity | 15241418 | SIGNOR-232138 |
| CDK4 | GATA4 | Ser160 | GFAGSYSsPYPAYMA | phosphorylation up-regulates activity | 25241353 | SIGNOR-279148 |
| CDK4 | TFE3 | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279514 | |
| CDK4 | RBL1 | Thr369 | KRSFAPStPLTGRRY | phosphorylation up-regulates activity | 12006580 | SIGNOR-250765 |
| CDK4 | FOXM1 | Thr627 | TPESWRLtPPAKVGG | phosphorylation up-regulates | 22094256 | SIGNOR-177263 |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates | 19114991 | SIGNOR-182979 |
| CDK4 | PELP1 | Ser991 | PALPPPEsPPKVQPE | phosphorylation up-regulates | 20807815 | SIGNOR-167774 |
| CDK4 | TFEB | – | phosphorylation up-regulates activity | 32662822 | SIGNOR-279450 | |
| CDK4 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | phosphorylation unknown | 15241418 | SIGNOR-250766 |
| CDK4 | FOXM1 | Ser4 | sPRRPLIL | phosphorylation up-regulates | 22094256 | SIGNOR-177251 |
| CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates | 23336272 | SIGNOR-200487 |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 19114991 | SIGNOR-182822 |
| CDK4 | RB1 | Ser249 | AVIPINGsPRTPRRG | phosphorylation down-regulates | 15809340 | SIGNOR-135181 |
| CDK4 | TOB2 | Ser254 | PAPQSQLsPNAKEFV | phosphorylation up-regulates activity | 32404348 | SIGNOR-273602 |
| CDK4 | RB1 | Ser780 | STRPPTLsPIPHIPR | phosphorylation down-regulates | 23336272 | SIGNOR-200483 |
| CDK4 | KAT2A | Thr272 | LNYWKLEtPAQFRQR | phosphorylation up-regulates activity | 24870244 | SIGNOR-275495 |
| CDK4 | PAX3 | Ser430 | TTVSASCsQRLDHMK | phosphorylation up-regulates activity | 23469153 | SIGNOR-278512 |
| CDK4 | RB1 | Thr826 | LPTPTKMtPRSRILV | phosphorylation down-regulates | 9139732 | SIGNOR-47899 |
| CDK4 | SMAD3 | Thr179 | PQSNIPEtPPPGYLS | phosphorylation down-regulates activity | 15241418 | SIGNOR-232146 |
| CDK4 | PELP1 | Ser477 | ADALKLRsPRGSPDG | phosphorylation up-regulates | 20807815 | SIGNOR-167770 |
| CDK4 | PRDX1 | Thr90 | CHLAWVNtPKKQGGL | phosphorylation down-regulates | 11986303 | SIGNOR-87105 |
| CDK4 | FOXM1 | – | phosphorylation up-regulates | 22094256 | SIGNOR-177266 | |
| CDK4 | RBL1 | Ser964 | MMDAPPLsPFPHIKQ | phosphorylation up-regulates activity | 12006580 | SIGNOR-250764 |
| CDK4 | WDR77 | Thr5 | tPPPLVPP | phosphorylation up-regulates activity | 20951943 | SIGNOR-279019 |
| CDK4 | CELF1 | Ser302 | TSSGSSPsSSSSNSV | phosphorylation up-regulates activity | 16931514 | SIGNOR-262735 |
| CDK4 | FOXO1 | Ser430 | KYTYGQSsMSPLPQM | phosphorylation up-regulates activity | 23469153 | SIGNOR-278377 |
| CDK4 | KAT2A | Ser372 | EEIYGANsPIWESGF | phosphorylation up-regulates activity | 24870244 | SIGNOR-275494 |
| CDK4 | RUNX3 | Ser356 | SSSGGDRsPTRMLAS | phosphorylation down-regulates | 19351720 | SIGNOR-185120 |
| CDK4 | GATA4 | Ser105 | AYTPPPVsPRFSFPG | phosphorylation down-regulates quantity by destabilization | 21447557 | SIGNOR-276317 |
| CDK4 | FOXM1 | Thr611 | ETLPISStPSKSVLP | phosphorylation up-regulates | 22094256 | SIGNOR-177255 |
| CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-153450 |
| CDK4 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | phosphorylation down-regulates activity | 15241418 | SIGNOR-232142 |
| CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-159849 |
| CDK4 | KAT2A | – | phosphorylation up-regulates activity | 32827753 | SIGNOR-279018 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK4 | phosphorylation up-regulates → | APP PThr743 | phosphorylation down-regulates ⊣ | APP | 30881282 | SIGNOR-280214 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182983 |
| CDK4 | phosphorylation up-regulates → | RBL1 PSer650 | phosphorylation up-regulates → | RBL1 | 12006580 | SIGNOR-250763 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr620 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177259 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer811 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135185 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer208 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250767 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr8 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232138 |
| CDK4 | phosphorylation up-regulates → | GATA4 PSer160 | phosphorylation up-regulates → | GATA4 | 25241353 | SIGNOR-279148 |
| CDK4 | phosphorylation up-regulates → | RBL1 PThr369 | phosphorylation up-regulates → | RBL1 | 12006580 | SIGNOR-250765 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr627 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177263 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182979 |
| CDK4 | phosphorylation up-regulates → | PELP1 PSer991 | phosphorylation up-regulates → | PELP1 | 20807815 | SIGNOR-167774 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer204 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-250766 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PSer4 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177251 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-200487 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 19114991 | SIGNOR-182822 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer249 | phosphorylation down-regulates ⊣ | RB1 | 15809340 | SIGNOR-135181 |
| CDK4 | phosphorylation up-regulates → | TOB2 PSer254 | phosphorylation up-regulates → | TOB2 | 32404348 | SIGNOR-273602 |
| CDK4 | phosphorylation up-regulates → | RB1 PSer780 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-200483 |
| CDK4 | phosphorylation up-regulates → | KAT2A PThr272 | phosphorylation up-regulates → | KAT2A | 24870244 | SIGNOR-275495 |
| CDK4 | phosphorylation up-regulates → | PAX3 PSer430 | phosphorylation up-regulates → | PAX3 | 23469153 | SIGNOR-278512 |
| CDK4 | phosphorylation up-regulates → | RB1 PThr826 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-47899 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PThr179 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232146 |
| CDK4 | phosphorylation up-regulates → | PELP1 PSer477 | phosphorylation up-regulates → | PELP1 | 20807815 | SIGNOR-167770 |
| CDK4 | phosphorylation up-regulates → | PRDX1 PThr90 | phosphorylation down-regulates ⊣ | PRDX1 | 11986303 | SIGNOR-87105 |
| CDK4 | phosphorylation up-regulates → | RBL1 PSer964 | phosphorylation up-regulates → | RBL1 | 12006580 | SIGNOR-250764 |
| CDK4 | phosphorylation up-regulates → | WDR77 PThr5 | phosphorylation up-regulates → | WDR77 | 20951943 | SIGNOR-279019 |
| CDK4 | phosphorylation up-regulates → | CELF1 PSer302 | phosphorylation up-regulates → | CELF1 | 16931514 | SIGNOR-262735 |
| CDK4 | phosphorylation up-regulates → | FOXO1 PSer430 | phosphorylation up-regulates → | FOXO1 | 23469153 | SIGNOR-278377 |
| CDK4 | phosphorylation up-regulates → | KAT2A PSer372 | phosphorylation up-regulates → | KAT2A | 24870244 | SIGNOR-275494 |
| CDK4 | phosphorylation up-regulates → | RUNX3 PSer356 | phosphorylation down-regulates ⊣ | RUNX3 | 19351720 | SIGNOR-185120 |
| CDK4 | phosphorylation up-regulates → | GATA4 PSer105 | phosphorylation down-regulates ⊣ | GATA4 | 21447557 | SIGNOR-276317 |
| CDK4 | phosphorylation up-regulates → | FOXM1 PThr611 | phosphorylation up-regulates → | FOXM1 | 22094256 | SIGNOR-177255 |
| CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-153450 |
| CDK4 | phosphorylation up-regulates → | SMAD3 PSer213 | phosphorylation down-regulates ⊣ | SMAD3 | 15241418 | SIGNOR-232142 |
| CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-159849 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK4 | phosphorylation down-regulates quantity by destabilization | APP | SIGNOR-280214 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182983 |
| CDK4 | phosphorylation → up-regulates activity | RBL1 | SIGNOR-250763 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177259 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-135185 |
| CDK4 | phosphorylation → unknown | SMAD3 | SIGNOR-250767 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232138 |
| CDK4 | phosphorylation → up-regulates activity | GATA4 | SIGNOR-279148 |
| CDK4 | phosphorylation → up-regulates activity | TFE3 | SIGNOR-279514 |
| CDK4 | phosphorylation → up-regulates activity | RBL1 | SIGNOR-250765 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177263 |
| CDK4 | phosphorylation down-regulates | SMAD3 | SIGNOR-182979 |
| CDK4 | phosphorylation → up-regulates | PELP1 | SIGNOR-167774 |
| CDK4 | phosphorylation → up-regulates activity | TFEB | SIGNOR-279450 |
| CDK4 | phosphorylation → unknown | SMAD3 | SIGNOR-250766 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177251 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-200487 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-182822 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-135181 |
| CDK4 | phosphorylation → up-regulates activity | TOB2 | SIGNOR-273602 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-200483 |
| CDK4 | phosphorylation → up-regulates activity | KAT2A | SIGNOR-275495 |
| CDK4 | phosphorylation → up-regulates activity | PAX3 | SIGNOR-278512 |
| CDK4 | phosphorylation down-regulates | RB1 | SIGNOR-47899 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232146 |
| CDK4 | phosphorylation → up-regulates | PELP1 | SIGNOR-167770 |
| CDK4 | phosphorylation down-regulates | PRDX1 | SIGNOR-87105 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177266 |
| CDK4 | phosphorylation → up-regulates activity | RBL1 | SIGNOR-250764 |
| CDK4 | phosphorylation → up-regulates activity | WDR77 | SIGNOR-279019 |
| CDK4 | phosphorylation → up-regulates activity | CELF1 | SIGNOR-262735 |
| CDK4 | phosphorylation → up-regulates activity | FOXO1 | SIGNOR-278377 |
| CDK4 | phosphorylation → up-regulates activity | KAT2A | SIGNOR-275494 |
| CDK4 | phosphorylation down-regulates | RUNX3 | SIGNOR-185120 |
| CDK4 | phosphorylation down-regulates quantity by destabilization | GATA4 | SIGNOR-276317 |
| CDK4 | phosphorylation → up-regulates | FOXM1 | SIGNOR-177255 |
| CDK4 | phosphorylation down-regulates | BRCA1 | SIGNOR-153450 |
| CDK4 | phosphorylation → down-regulates activity | SMAD3 | SIGNOR-232142 |
| CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-159849 |
| CDK4 | phosphorylation → up-regulates activity | KAT2A | SIGNOR-279018 |