Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CAK complex	CDK4	Thr172	YSYQMALtPVVVTLW	phosphorylation up-regulates	8139570	SIGNOR-269329
YES1	CDK4	Tyr17	AEIGVGAyGTVYKAR	phosphorylation down-regulates	18479465	SIGNOR-178624
CDC25A	CDK4	Tyr17	AEIGVGAyGTVYKAR	dephosphorylation up-regulates activity	23429262	SIGNOR-267568
CDK7	CDK4	Thr172	YSYQMALtPVVVTLW	phosphorylation up-regulates	8139570	SIGNOR-36549
CDC25A	CDK4	Tyr17	AEIGVGAyGTVYKAR	dephosphorylation up-regulates activity	27485204	SIGNOR-277138

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CAK complex	phosphorylation up-regulates →	CDK4 PThr172	phosphorylation up-regulates →	CDK4	8139570	SIGNOR-269329
YES1	phosphorylation up-regulates →	CDK4 PTyr17	phosphorylation down-regulates ⊣	CDK4	18479465	SIGNOR-178624
CDC25A	dephosphorylation down-regulates ⊣	CDK4 PTyr17	dephosphorylation down-regulates ⊣	CDK4	23429262	SIGNOR-267568
CDK7	phosphorylation up-regulates →	CDK4 PThr172	phosphorylation up-regulates →	CDK4	8139570	SIGNOR-36549
CDC25A	dephosphorylation down-regulates ⊣	CDK4 PTyr17	dephosphorylation down-regulates ⊣	CDK4	27485204	SIGNOR-277138

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CAK complex	phosphorylation → up-regulates	CDK4	SIGNOR-269329
YES1	phosphorylation down-regulates	CDK4	SIGNOR-178624
CDC25A	dephosphorylation → up-regulates activity	CDK4	SIGNOR-267568
CDK7	phosphorylation → up-regulates	CDK4	SIGNOR-36549
CDC25A	dephosphorylation → up-regulates activity	CDK4	SIGNOR-277138