| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| YES1 | CDK4 | Tyr17 | AEIGVGAyGTVYKAR | phosphorylation down-regulates | 18479465 | SIGNOR-178624 |
| CDC25A | CDK4 | Tyr17 | AEIGVGAyGTVYKAR | dephosphorylation up-regulates activity | 23429262 | SIGNOR-267568 |
| CDC25A | CDK4 | Tyr17 | AEIGVGAyGTVYKAR | dephosphorylation up-regulates activity | 27485204 | SIGNOR-277138 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| YES1 | phosphorylation up-regulates → | CDK4 PTyr17 | phosphorylation down-regulates ⊣ | CDK4 | 18479465 | SIGNOR-178624 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK4 PTyr17 | dephosphorylation down-regulates ⊣ | CDK4 | 23429262 | SIGNOR-267568 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK4 PTyr17 | dephosphorylation down-regulates ⊣ | CDK4 | 27485204 | SIGNOR-277138 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| YES1 | phosphorylation down-regulates | CDK4 | SIGNOR-178624 |
| CDC25A | dephosphorylation → up-regulates activity | CDK4 | SIGNOR-267568 |
| CDC25A | dephosphorylation → up-regulates activity | CDK4 | SIGNOR-277138 |
