| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | PRPS2 | Thr228 | DMADTCGtICHAADK | phosphorylation up-regulates activity | 34343500 | SIGNOR-277317 |
| LATS2 | PRPS2 | Thr285 | EDKMKHCtKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276507 |
| AMPK | PRPS2 | Ser180 | GGAKRVTsIADRLNV | phosphorylation down-regulates activity | 29074724 | SIGNOR-265732 |
| PRKAA1 | PRPS2 | Ser180 | GGAKRVTsIADRLNV | phosphorylation down-regulates activity | 29074724 | SIGNOR-265731 |
| LATS1 | PRPS2 | Thr285 | EDKMKHCtKIQVIDI | phosphorylation down-regulates quantity by destabilization | 34465890 | SIGNOR-276506 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | PRPS2 PThr228 | phosphorylation up-regulates → | PRPS2 | 34343500 | SIGNOR-277317 |
| LATS2 | phosphorylation up-regulates → | PRPS2 PThr285 | phosphorylation down-regulates ⊣ | PRPS2 | 34465890 | SIGNOR-276507 |
| AMPK | phosphorylation up-regulates → | PRPS2 PSer180 | phosphorylation down-regulates ⊣ | PRPS2 | 29074724 | SIGNOR-265732 |
| PRKAA1 | phosphorylation up-regulates → | PRPS2 PSer180 | phosphorylation down-regulates ⊣ | PRPS2 | 29074724 | SIGNOR-265731 |
| LATS1 | phosphorylation up-regulates → | PRPS2 PThr285 | phosphorylation down-regulates ⊣ | PRPS2 | 34465890 | SIGNOR-276506 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → up-regulates activity | PRPS2 | SIGNOR-277317 |
| LATS2 | phosphorylation down-regulates quantity by destabilization | PRPS2 | SIGNOR-276507 |
| AMPK | phosphorylation → down-regulates activity | PRPS2 | SIGNOR-265732 |
| PRKAA1 | phosphorylation → down-regulates activity | PRPS2 | SIGNOR-265731 |
| LATS1 | phosphorylation down-regulates quantity by destabilization | PRPS2 | SIGNOR-276506 |
