Entity Details

Name PCNA
ID P12004
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ABL1PCNATyr211QLTFALRyLNFFTKAphosphorylation
up-regulates activity		23542172SIGNOR-279389
IGF1RPCNATyr133LGIPEQEySCVVKMPphosphorylation
up-regulates activity		28924044SIGNOR-277254
IGF1RPCNATyr60RSEGFDTyRCDRNLAphosphorylation
up-regulates activity		28924044SIGNOR-277253
EGFRPCNATyr211QLTFALRyLNFFTKAphosphorylation
up-regulates		17115032SIGNOR-150852
IGF1RPCNATyr250DMGHLKYyLAPKIEDphosphorylation
up-regulates activity		28924044SIGNOR-277252
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ABL1phosphorylation
up-regulates
→
PCNA
PTyr211		phosphorylation
up-regulates
→		PCNA23542172SIGNOR-279389
IGF1Rphosphorylation
up-regulates
→
PCNA
PTyr133		phosphorylation
up-regulates
→		PCNA28924044SIGNOR-277254
IGF1Rphosphorylation
up-regulates
→
PCNA
PTyr60		phosphorylation
up-regulates
→		PCNA28924044SIGNOR-277253
EGFRphosphorylation
up-regulates
→
PCNA
PTyr211		phosphorylation
up-regulates
→		PCNA17115032SIGNOR-150852
IGF1Rphosphorylation
up-regulates
→
PCNA
PTyr250		phosphorylation
up-regulates
→		PCNA28924044SIGNOR-277252
Regulator Mechanism/Effect Target SIGNOR-ID
ABL1phosphorylation
→
up-regulates activity 		PCNASIGNOR-279389
IGF1Rphosphorylation
→
up-regulates activity 		PCNASIGNOR-277254
IGF1Rphosphorylation
→
up-regulates activity 		PCNASIGNOR-277253
EGFRphosphorylation
→
up-regulates 		PCNASIGNOR-150852
IGF1Rphosphorylation
→
up-regulates activity 		PCNASIGNOR-277252