Entity Details

Name NEFH
ID P12036
Role substrate
Enzymatic Domains
IF rod 97-413
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1NEFHSer518 SPEKEAKsPVKEEAKphosphorylation
up-regulates activity
9592082SIGNOR-249423
GSK3ANEFHphosphorylation
down-regulates activity
8627328SIGNOR-279783
MAPK1NEFHSer526 PVKEEAKsPAEAKSPphosphorylation
up-regulates activity
9592082SIGNOR-249424
GSK3BNEFHSer503 GGEEETKsPPAEEAAphosphorylation
down-regulates
12130654SIGNOR-90668
MAPK1NEFHSer532 KSPAEAKsPEKEEAKphosphorylation
up-regulates activity
9592082SIGNOR-249425
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
NEFH
PSer518
phosphorylation
up-regulates
NEFH9592082SIGNOR-249423
MAPK1phosphorylation
up-regulates
NEFH
PSer526
phosphorylation
up-regulates
NEFH9592082SIGNOR-249424
GSK3Bphosphorylation
up-regulates
NEFH
PSer503
phosphorylation
down-regulates
NEFH12130654SIGNOR-90668
MAPK1phosphorylation
up-regulates
NEFH
PSer532
phosphorylation
up-regulates
NEFH9592082SIGNOR-249425
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation

up-regulates activity
NEFHSIGNOR-249423
GSK3Aphosphorylation

down-regulates activity
NEFHSIGNOR-279783
MAPK1phosphorylation

up-regulates activity
NEFHSIGNOR-249424
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates
NEFHSIGNOR-90668
MAPK1phosphorylation

up-regulates activity
NEFHSIGNOR-249425