| Name | FCGR2A |
| ID | P12318 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 39-118
Ig-like C2-type 2 122-204 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | FCGR2A | Tyr304 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-249337 |
| LYN | FCGR2A | Tyr304 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-249379 |
| SYK | FCGR2A | Tyr281 | LEETNNDyETADGGY | phosphorylation up-regulates activity | 8756631 | SIGNOR-247590 |
| BLK | FCGR2A | Tyr304 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-249312 |
| SYK | FCGR2A | Tyr304 | TDDDKNIyLTLPPND | phosphorylation up-regulates activity | 8756631 | SIGNOR-246551 |
| FYN | FCGR2A | Tyr288 | YETADGGyMTLNPRA | phosphorylation up-regulates activity | 8756631 | SIGNOR-249336 |
| BLK | FCGR2A | Tyr288 | YETADGGyMTLNPRA | phosphorylation up-regulates activity | 8756631 | SIGNOR-249311 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | FCGR2A PTyr304 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249337 |
| LYN | phosphorylation up-regulates → | FCGR2A PTyr304 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249379 |
| SYK | phosphorylation up-regulates → | FCGR2A PTyr281 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-247590 |
| BLK | phosphorylation up-regulates → | FCGR2A PTyr304 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249312 |
| SYK | phosphorylation up-regulates → | FCGR2A PTyr304 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-246551 |
| FYN | phosphorylation up-regulates → | FCGR2A PTyr288 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249336 |
| BLK | phosphorylation up-regulates → | FCGR2A PTyr288 | phosphorylation up-regulates → | FCGR2A | 8756631 | SIGNOR-249311 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249337 |
| LYN | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249379 |
| SYK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-247590 |
| BLK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249312 |
| SYK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-246551 |
| FYN | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249336 |
| BLK | phosphorylation → up-regulates activity | FCGR2A | SIGNOR-249311 |