Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AURKA	SKI	Ser383 View in OncoXplorer	LSAFRPWsPAVSASE	phosphorylation down-regulates quantity by destabilization	26138431	SIGNOR-276917
AKT1	SKI	Thr458	QPRKRKLtVDTPGAP	phosphorylation down-regulates	19875456	SIGNOR-252527
AURKA	SKI	Ser326	RRVPRVSsEPPASIR	phosphorylation down-regulates quantity by destabilization	26138431	SIGNOR-276918
AKT	SKI	Thr458	QPRKRKLtVDTPGAP	phosphorylation down-regulates	19875456	SIGNOR-188969

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AURKA	phosphorylation up-regulates →	SKI PSer383	phosphorylation down-regulates ⊣	SKI	26138431	SIGNOR-276917
AKT1	phosphorylation up-regulates →	SKI PThr458	phosphorylation down-regulates ⊣	SKI	19875456	SIGNOR-252527
AURKA	phosphorylation up-regulates →	SKI PSer326	phosphorylation down-regulates ⊣	SKI	26138431	SIGNOR-276918
AKT	phosphorylation up-regulates →	SKI PThr458	phosphorylation down-regulates ⊣	SKI	19875456	SIGNOR-188969

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AURKA	phosphorylation down-regulates quantity by destabilization	SKI	SIGNOR-276917
AKT1	phosphorylation down-regulates	SKI	SIGNOR-252527
AURKA	phosphorylation down-regulates quantity by destabilization	SKI	SIGNOR-276918
AKT	phosphorylation down-regulates	SKI	SIGNOR-188969