Entity Details

Name AKT1_Thr458
ID P12755
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AKT1SKIThr458QPRKRKLtVDTPGAPphosphorylation
down-regulates		19875456SIGNOR-252527
AKTSKIThr458QPRKRKLtVDTPGAPphosphorylation
down-regulates		19875456SIGNOR-188969
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AKT1phosphorylation
up-regulates
→
SKI
PThr458		phosphorylation
down-regulates
⊣		SKI19875456SIGNOR-252527
AKTphosphorylation
up-regulates
→
SKI
PThr458		phosphorylation
down-regulates
⊣		SKI19875456SIGNOR-188969
Regulator Mechanism/Effect Target SIGNOR-ID
AKT1phosphorylation
img/direct_inhibition.png
down-regulates 		SKISIGNOR-252527
AKTphosphorylation
img/direct_inhibition.png
down-regulates 		SKISIGNOR-188969