Entity Details

Name ACTN1
ID P12814
Role substrate
Enzymatic Domains
Calponin-homology (CH) 1 31-135
PROSITE-ProRule
Calponin-homology (CH) 2 144-250
PROSITE-ProRule
EF-hand 1 746-781
PROSITE-ProRule
EF-hand 2 787-822
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN1ACTN1Tyr12DSQQTNDyMQPEEDWdephosphorylation
up-regulates		16291744SIGNOR-141634
PTK2ACTN1Tyr12DSQQTNDyMQPEEDWphosphorylation
down-regulates activity		11369769SIGNOR-108329
PTK2ACTN1Tyr12DSQQTNDyMQPEEDWphosphorylation
down-regulates		23454549SIGNOR-192126
PTPN1ACTN1Tyr12DSQQTNDyMQPEEDWdephosphorylation
down-regulates activity		16291744SIGNOR-270539
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN1dephosphorylation
down-regulates
⊣
ACTN1
PTyr12		dephosphorylation
down-regulates
⊣		ACTN116291744SIGNOR-141634
PTK2phosphorylation
up-regulates
→
ACTN1
PTyr12		phosphorylation
down-regulates
⊣		ACTN111369769SIGNOR-108329
PTK2phosphorylation
up-regulates
→
ACTN1
PTyr12		phosphorylation
down-regulates
⊣		ACTN123454549SIGNOR-192126
PTPN1dephosphorylation
down-regulates
⊣
ACTN1
PTyr12		dephosphorylation
up-regulates
→		ACTN116291744SIGNOR-270539
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN1dephosphorylation
→
up-regulates 		ACTN1SIGNOR-141634
PTK2phosphorylation
→
down-regulates activity 		ACTN1SIGNOR-108329
PTK2phosphorylation
img/direct_inhibition.png
down-regulates 		ACTN1SIGNOR-192126
PTPN1dephosphorylation
→
down-regulates activity 		ACTN1SIGNOR-270539