Entity Details

Name PTK2_Tyr12
ID P12814
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTK2ACTN1Tyr12DSQQTNDyMQPEEDWphosphorylation
down-regulates activity		11369769SIGNOR-108329
PTPN1ACTN1Tyr12DSQQTNDyMQPEEDWdephosphorylation
down-regulates activity		16291744SIGNOR-270539
PTPN1ACTN1Tyr12DSQQTNDyMQPEEDWdephosphorylation
up-regulates		16291744SIGNOR-141634
PTK2ACTN1Tyr12DSQQTNDyMQPEEDWphosphorylation
down-regulates		23454549SIGNOR-192126
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTK2phosphorylation
up-regulates
→
ACTN1
PTyr12		phosphorylation
down-regulates
⊣		ACTN111369769SIGNOR-108329
PTPN1dephosphorylation
down-regulates
⊣
ACTN1
PTyr12		dephosphorylation
up-regulates
→		ACTN116291744SIGNOR-270539
PTPN1dephosphorylation
down-regulates
⊣
ACTN1
PTyr12		dephosphorylation
down-regulates
⊣		ACTN116291744SIGNOR-141634
PTK2phosphorylation
up-regulates
→
ACTN1
PTyr12		phosphorylation
down-regulates
⊣		ACTN123454549SIGNOR-192126
Regulator Mechanism/Effect Target SIGNOR-ID
PTK2phosphorylation
→
down-regulates activity 		ACTN1SIGNOR-108329
PTPN1dephosphorylation
→
down-regulates activity 		ACTN1SIGNOR-270539
PTPN1dephosphorylation
→
up-regulates 		ACTN1SIGNOR-141634
PTK2phosphorylation
img/direct_inhibition.png
down-regulates 		ACTN1SIGNOR-192126