| Name | CDH1 |
| ID | P12830 |
| Role | substrate |
| Enzymatic Domains |
Cadherin 1 155-262 PROSITE-ProRule
Cadherin 2 263-375 PROSITE-ProRule
Cadherin 3 376-486 PROSITE-ProRule
Cadherin 4 487-593 PROSITE-ProRule
Cadherin 5 594-697 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | CDH1 | Ser838 | LVFDYEGsGSEAASL | phosphorylation up-regulates activity | 10671552 | SIGNOR-250839 |
| CDK5 | CDH1 | – | phosphorylation down-regulates activity | 22836916 | SIGNOR-279679 | |
| CDK1 | CDH1 | – | phosphorylation up-regulates activity | 18500339 | SIGNOR-280204 | |
| CyclinA2/CDK2 | CDH1 | Thr40 | DAESYTFtVPRRHLE | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274052 |
| CDK2 | CDH1 | – | phosphorylation down-regulates activity | 23972993 | SIGNOR-279512 | |
| CSNK1D | CDH1 | Ser844 | GSGSEAAsLSSLNSS | phosphorylation down-regulates activity | 17353278 | SIGNOR-274046 |
| CSNK2A1 | CDH1 | Ser853 | SSLNSSEsDKDQDYD | phosphorylation up-regulates activity | 10671552 | SIGNOR-250841 |
| PLK1 | CDH1 | Ser146 | LLTFPNSsPGLRRQK | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274054 |
| CSNK1A1 | CDH1 | Ser844 | GSGSEAAsLSSLNSS | phosphorylation down-regulates activity | 17353278 | SIGNOR-274045 |
| SRC | CDH1 | Tyr797 | TLMSVPRyLPRPANP | phosphorylation down-regulates quantity by destabilization | 31286874 | SIGNOR-274048 |
| CyclinA2/CDK2 | CDH1 | Ser36 | HPGFDAEsYTFTVPR | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274051 |
| SRC | CDH1 | Tyr754 | DTRDNVYyYDEEGGG | phosphorylation down-regulates quantity by destabilization | 27203386 | SIGNOR-278497 |
| CDK2 | CDH1 | Thr40 | DAESYTFtVPRRHLE | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274050 |
| CHEK1 | CDH1 | – | phosphorylation down-regulates activity | 32345958 | SIGNOR-278396 | |
| TBK1 | CDH1 | – | phosphorylation down-regulates activity | 33310066 | SIGNOR-278996 | |
| SRC | CDH1 | Tyr753 | DDTRDNVyYYDEEGG | phosphorylation down-regulates quantity by destabilization | 27203386 | SIGNOR-278498 |
| CDK2 | CDH1 | Ser36 | HPGFDAEsYTFTVPR | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274049 |
| CSNK1E | CDH1 | Ser844 | GSGSEAAsLSSLNSS | phosphorylation down-regulates activity | 17353278 | SIGNOR-274047 |
| PRKD1 | CDH1 | – | phosphorylation up-regulates | 15695390 | SIGNOR-133856 | |
| PRKCD | CDH1 | Thr790 | TRNDVAPtLMSVPRY | phosphorylation down-regulates activity | 27203386 | SIGNOR-260893 |
| CSNK2A1 | CDH1 | Ser851 | SLSSLNSsESDKDQD | phosphorylation up-regulates activity | 10671552 | SIGNOR-250840 |
| GSK3B | CDH1 | Ser847 | SEAASLSsLNSSESD | phosphorylation up-regulates activity | 10671552 | SIGNOR-251225 |
| MAK | CDH1 | – | phosphorylation down-regulates | 21986944 | SIGNOR-278486 | |
| PLK1 | CDH1 | – | phosphorylation down-regulates quantity by destabilization | 23972993 | SIGNOR-274053 | |
| CDC14B | CDH1 | – | dephosphorylation up-regulates activity | 18662541 | SIGNOR-277017 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | CDH1 PSer838 | phosphorylation up-regulates → | CDH1 | 10671552 | SIGNOR-250839 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDH1 PThr40 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274052 |
| CSNK1D | phosphorylation up-regulates → | CDH1 PSer844 | phosphorylation down-regulates ⊣ | CDH1 | 17353278 | SIGNOR-274046 |
| CSNK2A1 | phosphorylation up-regulates → | CDH1 PSer853 | phosphorylation up-regulates → | CDH1 | 10671552 | SIGNOR-250841 |
| PLK1 | phosphorylation up-regulates → | CDH1 PSer146 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274054 |
| CSNK1A1 | phosphorylation up-regulates → | CDH1 PSer844 | phosphorylation down-regulates ⊣ | CDH1 | 17353278 | SIGNOR-274045 |
| SRC | phosphorylation up-regulates → | CDH1 PTyr797 | phosphorylation down-regulates ⊣ | CDH1 | 31286874 | SIGNOR-274048 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDH1 PSer36 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274051 |
| SRC | phosphorylation up-regulates → | CDH1 PTyr754 | phosphorylation down-regulates ⊣ | CDH1 | 27203386 | SIGNOR-278497 |
| CDK2 | phosphorylation up-regulates → | CDH1 PThr40 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274050 |
| SRC | phosphorylation up-regulates → | CDH1 PTyr753 | phosphorylation down-regulates ⊣ | CDH1 | 27203386 | SIGNOR-278498 |
| CDK2 | phosphorylation up-regulates → | CDH1 PSer36 | phosphorylation down-regulates ⊣ | CDH1 | 23972993 | SIGNOR-274049 |
| CSNK1E | phosphorylation up-regulates → | CDH1 PSer844 | phosphorylation down-regulates ⊣ | CDH1 | 17353278 | SIGNOR-274047 |
| PRKCD | phosphorylation up-regulates → | CDH1 PThr790 | phosphorylation down-regulates ⊣ | CDH1 | 27203386 | SIGNOR-260893 |
| CSNK2A1 | phosphorylation up-regulates → | CDH1 PSer851 | phosphorylation up-regulates → | CDH1 | 10671552 | SIGNOR-250840 |
| GSK3B | phosphorylation up-regulates → | CDH1 PSer847 | phosphorylation up-regulates → | CDH1 | 10671552 | SIGNOR-251225 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → up-regulates activity | CDH1 | SIGNOR-250839 |
| CDK5 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-279679 |
| CDK1 | phosphorylation → up-regulates activity | CDH1 | SIGNOR-280204 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274052 |
| CDK2 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-279512 |
| CSNK1D | phosphorylation → down-regulates activity | CDH1 | SIGNOR-274046 |
| CSNK2A1 | phosphorylation → up-regulates activity | CDH1 | SIGNOR-250841 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274054 |
| CSNK1A1 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-274045 |
| SRC | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274048 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274051 |
| SRC | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-278497 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274050 |
| CHEK1 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-278396 |
| TBK1 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-278996 |
| SRC | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-278498 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274049 |
| CSNK1E | phosphorylation → down-regulates activity | CDH1 | SIGNOR-274047 |
| PRKD1 | phosphorylation → up-regulates | CDH1 | SIGNOR-133856 |
| PRKCD | phosphorylation → down-regulates activity | CDH1 | SIGNOR-260893 |
| CSNK2A1 | phosphorylation → up-regulates activity | CDH1 | SIGNOR-250840 |
| GSK3B | phosphorylation → up-regulates activity | CDH1 | SIGNOR-251225 |
| MAK | phosphorylation down-regulates | CDH1 | SIGNOR-278486 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CDH1 | SIGNOR-274053 |
| CDC14B | dephosphorylation → up-regulates activity | CDH1 | SIGNOR-277017 |