| Name | SRC |
| ID | P12931 |
| Role | substrate |
| Enzymatic Domains |
SH3 84-145 PROSITE-ProRule
SH2 151-248 PROSITE-ProRule
Protein kinase 270-523 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIK3CG | SRC | Ser39 | FPASQTPsKPASADG | phosphorylation up-regulates activity | 27169346 | SIGNOR-279748 |
| SRC | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates activity | 8755732 | SIGNOR-43315 |
| PTPN2 | SRC | – | dephosphorylation down-regulates activity | 33603165 | SIGNOR-276996 | |
| MAPK9 | SRC | – | phosphorylation up-regulates activity | 25377781 | SIGNOR-279221 | |
| CSK | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates | 18614016 | SIGNOR-179417 |
| ACP1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 19088431 | SIGNOR-248454 |
| PRKACA | SRC | Ser17 | DASQRRRsLEPAENV | phosphorylation up-regulates activity | 11804588 | SIGNOR-247988 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 7691597 | SIGNOR-32014 |
| PTPRJ | SRC | Tyr1320 | Y>1319 | phosphorylation up-regulates activity | 24583284 | SIGNOR-277877 |
| FGR | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation unknown | 9208935 | SIGNOR-251145 |
| PTPN11 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248671 |
| PTPN21 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15143158 | SIGNOR-248725 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248437 |
| PTPRG | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254726 |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248472 |
| PRKACA | SRC | Ser17 | DASQRRRsLEPAENV | phosphorylation up-regulates | 11804588 | SIGNOR-114277 |
| PIK3CG | SRC | Ser70 | LFGGFNSsDTVTSPQ | phosphorylation up-regulates activity | 27169346 | SIGNOR-277225 |
| PTPN13 | SRC | – | dephosphorylation down-regulates activity | 19307596 | SIGNOR-277125 | |
| GSK3B | SRC | Ser43 | QTPSKPAsADGHRGP | phosphorylation up-regulates activity | 33388549 | SIGNOR-278442 |
| PTPRB | SRC | – | dephosphorylation down-regulates activity | 27314562 | SIGNOR-277132 | |
| CHEK1 | SRC | Ser51 | ADGHRGPsAAFAPAA | phosphorylation up-regulates activity | 29954829 | SIGNOR-278332 |
| CHKA | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates activity | 28784162 | SIGNOR-279731 |
| PTPN12 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 19350555 | SIGNOR-277086 |
| PRKCD | SRC | Ser12 | KSKPKDAsQRRRSLE | phosphorylation up-regulates activity | 18069897 | SIGNOR-247974 |
| PTEN | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22482061 | SIGNOR-277009 |
| PTPRG | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254725 |
| PTPRJ | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22898603 | SIGNOR-276978 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15735685 | SIGNOR-248705 |
| PTPN11 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 18482983 | SIGNOR-248670 |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 9261115 | SIGNOR-248473 |
| MAPK9 | SRC | – | phosphorylation up-regulates activity | 25377781 | SIGNOR-279222 | |
| SRC | SRC | Tyr216 | KLDSGGFyITSRTQF | phosphorylation up-regulates | 12753909 | SIGNOR-236246 |
| PRKCA | SRC | Ser12 | KSKPKDAsQRRRSLE | phosphorylation unknown | 2996780 | SIGNOR-248893 |
| PPP2CA | SRC | Ser12 | KSKPKDAsQRRRSLE | dephosphorylation down-regulates activity | 18069897 | SIGNOR-247970 |
| PTPN12 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 18482983 | SIGNOR-248659 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 26556953 | SIGNOR-276977 |
| SRC | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates | 7578094 | SIGNOR-29369 |
| PDGFRB | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 15489898 | SIGNOR-247979 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 10698938 | SIGNOR-248438 |
| GSK3B | SRC | Ser51 | ADGHRGPsAAFAPAA | phosphorylation up-regulates activity | 33388549 | SIGNOR-278443 |
| ROR1 | SRC | – | phosphorylation up-regulates | 22439932 | SIGNOR-196751 | |
| PTPRE | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15522235 | SIGNOR-238074 |
| PDGFRA | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 15489898 | SIGNOR-247984 |
| PTPN21 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 15143158 | SIGNOR-124774 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 12857726 | SIGNOR-103607 |
| CDK5 | SRC | Ser75 | NSSDTVTsPQRAGPL | phosphorylation up-regulates | 10544291 | SIGNOR-71950 |
| GSK3B | SRC | Ser493 | CPPECPEsLHDLMCQ | phosphorylation down-regulates activity | 33388549 | SIGNOR-277544 |
| SMO | SRC | – | phosphorylation up-regulates | 18455992 | SIGNOR-178610 | |
| GSK3B | SRC | Ser493 | CPPECPEsLHDLMCQ | phosphorylation up-regulates activity | 33388549 | SIGNOR-278444 |
| GSK3B | SRC | Ser43 | QTPSKPAsADGHRGP | phosphorylation down-regulates activity | 33388549 | SIGNOR-277543 |
| PTPRO | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25301722 | SIGNOR-277004 |
| PTK2 | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 17828307 | SIGNOR-278452 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248422 |
| PTPN2 | SRC | – | dephosphorylation down-regulates | 22080863 | SIGNOR-177116 | |
| PTPN1 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation up-regulates activity | 11007774 | SIGNOR-245299 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIK3CG | phosphorylation up-regulates → | SRC PSer39 | phosphorylation up-regulates → | SRC | 27169346 | SIGNOR-279748 |
| SRC | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 8755732 | SIGNOR-43315 |
| CSK | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 18614016 | SIGNOR-179417 |
| ACP1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 19088431 | SIGNOR-248454 |
| PRKACA | phosphorylation up-regulates → | SRC PSer17 | phosphorylation up-regulates → | SRC | 11804588 | SIGNOR-247988 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 7691597 | SIGNOR-32014 |
| PTPRJ | phosphorylation up-regulates → | SRC PTyr1320 | phosphorylation up-regulates → | SRC | 24583284 | SIGNOR-277877 |
| FGR | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 9208935 | SIGNOR-251145 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248671 |
| PTPN21 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15143158 | SIGNOR-248725 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248437 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254726 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248472 |
| PRKACA | phosphorylation up-regulates → | SRC PSer17 | phosphorylation up-regulates → | SRC | 11804588 | SIGNOR-114277 |
| PIK3CG | phosphorylation up-regulates → | SRC PSer70 | phosphorylation up-regulates → | SRC | 27169346 | SIGNOR-277225 |
| GSK3B | phosphorylation up-regulates → | SRC PSer43 | phosphorylation up-regulates → | SRC | 33388549 | SIGNOR-278442 |
| CHEK1 | phosphorylation up-regulates → | SRC PSer51 | phosphorylation up-regulates → | SRC | 29954829 | SIGNOR-278332 |
| CHKA | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 28784162 | SIGNOR-279731 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 19350555 | SIGNOR-277086 |
| PRKCD | phosphorylation up-regulates → | SRC PSer12 | phosphorylation up-regulates → | SRC | 18069897 | SIGNOR-247974 |
| PTEN | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22482061 | SIGNOR-277009 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254725 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22898603 | SIGNOR-276978 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15735685 | SIGNOR-248705 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 18482983 | SIGNOR-248670 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 9261115 | SIGNOR-248473 |
| SRC | phosphorylation up-regulates → | SRC PTyr216 | phosphorylation up-regulates → | SRC | 12753909 | SIGNOR-236246 |
| PRKCA | phosphorylation up-regulates → | SRC PSer12 | phosphorylation down-regulates ⊣ | SRC | 2996780 | SIGNOR-248893 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SRC PSer12 | dephosphorylation up-regulates → | SRC | 18069897 | SIGNOR-247970 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 18482983 | SIGNOR-248659 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 26556953 | SIGNOR-276977 |
| SRC | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 7578094 | SIGNOR-29369 |
| PDGFRB | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 15489898 | SIGNOR-247979 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 10698938 | SIGNOR-248438 |
| GSK3B | phosphorylation up-regulates → | SRC PSer51 | phosphorylation up-regulates → | SRC | 33388549 | SIGNOR-278443 |
| PTPRE | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15522235 | SIGNOR-238074 |
| PDGFRA | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 15489898 | SIGNOR-247984 |
| PTPN21 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15143158 | SIGNOR-124774 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 12857726 | SIGNOR-103607 |
| CDK5 | phosphorylation up-regulates → | SRC PSer75 | phosphorylation up-regulates → | SRC | 10544291 | SIGNOR-71950 |
| GSK3B | phosphorylation up-regulates → | SRC PSer493 | phosphorylation down-regulates ⊣ | SRC | 33388549 | SIGNOR-277544 |
| GSK3B | phosphorylation up-regulates → | SRC PSer493 | phosphorylation up-regulates → | SRC | 33388549 | SIGNOR-278444 |
| GSK3B | phosphorylation up-regulates → | SRC PSer43 | phosphorylation down-regulates ⊣ | SRC | 33388549 | SIGNOR-277543 |
| PTPRO | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25301722 | SIGNOR-277004 |
| PTK2 | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 17828307 | SIGNOR-278452 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248422 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation down-regulates ⊣ | SRC | 11007774 | SIGNOR-245299 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIK3CG | phosphorylation → up-regulates activity | SRC | SIGNOR-279748 |
| SRC | phosphorylation → down-regulates activity | SRC | SIGNOR-43315 |
| PTPN2 | dephosphorylation → down-regulates activity | SRC | SIGNOR-276996 |
| MAPK9 | phosphorylation → up-regulates activity | SRC | SIGNOR-279221 |
| CSK | phosphorylation down-regulates | SRC | SIGNOR-179417 |
| ACP1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248454 |
| PRKACA | phosphorylation → up-regulates activity | SRC | SIGNOR-247988 |
| PTPRA | dephosphorylation → up-regulates | SRC | SIGNOR-32014 |
| PTPRJ | phosphorylation → up-regulates activity | SRC | SIGNOR-277877 |
| FGR | phosphorylation → unknown | SRC | SIGNOR-251145 |
| PTPN11 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248671 |
| PTPN21 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248725 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248437 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254726 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248472 |
| PRKACA | phosphorylation → up-regulates | SRC | SIGNOR-114277 |
| PIK3CG | phosphorylation → up-regulates activity | SRC | SIGNOR-277225 |
| PTPN13 | dephosphorylation → down-regulates activity | SRC | SIGNOR-277125 |
| GSK3B | phosphorylation → up-regulates activity | SRC | SIGNOR-278442 |
| PTPRB | dephosphorylation → down-regulates activity | SRC | SIGNOR-277132 |
| CHEK1 | phosphorylation → up-regulates activity | SRC | SIGNOR-278332 |
| CHKA | phosphorylation → down-regulates activity | SRC | SIGNOR-279731 |
| PTPN12 | dephosphorylation → up-regulates activity | SRC | SIGNOR-277086 |
| PRKCD | phosphorylation → up-regulates activity | SRC | SIGNOR-247974 |
| PTEN | dephosphorylation → down-regulates activity | SRC | SIGNOR-277009 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254725 |
| PTPRJ | dephosphorylation → down-regulates activity | SRC | SIGNOR-276978 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-248705 |
| PTPN11 | dephosphorylation → down-regulates activity | SRC | SIGNOR-248670 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248473 |
| MAPK9 | phosphorylation → up-regulates activity | SRC | SIGNOR-279222 |
| SRC | phosphorylation → up-regulates | SRC | SIGNOR-236246 |
| PRKCA | phosphorylation → unknown | SRC | SIGNOR-248893 |
| PPP2CA | dephosphorylation → down-regulates activity | SRC | SIGNOR-247970 |
| PTPN12 | dephosphorylation → down-regulates activity | SRC | SIGNOR-248659 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-276977 |
| SRC | phosphorylation → up-regulates | SRC | SIGNOR-29369 |
| PDGFRB | phosphorylation → up-regulates activity | SRC | SIGNOR-247979 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248438 |
| GSK3B | phosphorylation → up-regulates activity | SRC | SIGNOR-278443 |
| ROR1 | phosphorylation → up-regulates | SRC | SIGNOR-196751 |
| PTPRE | dephosphorylation → up-regulates activity | SRC | SIGNOR-238074 |
| PDGFRA | phosphorylation → up-regulates activity | SRC | SIGNOR-247984 |
| PTPN21 | dephosphorylation → up-regulates | SRC | SIGNOR-124774 |
| PTPN1 | dephosphorylation → up-regulates | SRC | SIGNOR-103607 |
| CDK5 | phosphorylation → up-regulates | SRC | SIGNOR-71950 |
| GSK3B | phosphorylation → down-regulates activity | SRC | SIGNOR-277544 |
| SMO | phosphorylation → up-regulates | SRC | SIGNOR-178610 |
| GSK3B | phosphorylation → up-regulates activity | SRC | SIGNOR-278444 |
| GSK3B | phosphorylation → down-regulates activity | SRC | SIGNOR-277543 |
| PTPRO | dephosphorylation → down-regulates activity | SRC | SIGNOR-277004 |
| PTK2 | phosphorylation → up-regulates activity | SRC | SIGNOR-278452 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248422 |
| PTPN2 | dephosphorylation down-regulates | SRC | SIGNOR-177116 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-245299 |