| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN21 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15143158 | SIGNOR-248725 |
| PTPN12 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 19350555 | SIGNOR-277086 |
| CSK | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates | 18614016 | SIGNOR-179417 |
| FGR | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation unknown | 9208935 | SIGNOR-251145 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248437 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 10698938 | SIGNOR-248438 |
| CHKA | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates activity | 28784162 | SIGNOR-279731 |
| PTPN11 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248671 |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 9261115 | SIGNOR-248473 |
| PTPN21 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 15143158 | SIGNOR-124774 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 12857726 | SIGNOR-103607 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248422 |
| PTPRE | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15522235 | SIGNOR-238074 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 7691597 | SIGNOR-32014 |
| PTPN6 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248472 |
| ACP1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 19088431 | SIGNOR-248454 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 26556953 | SIGNOR-276977 |
| PTPRJ | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 15735685 | SIGNOR-248705 |
| SRC | SRC | Tyr530 | FTSTEPQyQPGENL | phosphorylation down-regulates activity | 8755732 | SIGNOR-43315 |
| PTPRG | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254726 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN21 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15143158 | SIGNOR-248725 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 19350555 | SIGNOR-277086 |
| CSK | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 18614016 | SIGNOR-179417 |
| FGR | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 9208935 | SIGNOR-251145 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248437 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 10698938 | SIGNOR-248438 |
| CHKA | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 28784162 | SIGNOR-279731 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248671 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 9261115 | SIGNOR-248473 |
| PTPN21 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15143158 | SIGNOR-124774 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 12857726 | SIGNOR-103607 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248422 |
| PTPRE | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15522235 | SIGNOR-238074 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 7691597 | SIGNOR-32014 |
| PTPN6 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248472 |
| ACP1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 19088431 | SIGNOR-248454 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 26556953 | SIGNOR-276977 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 15735685 | SIGNOR-248705 |
| SRC | phosphorylation up-regulates → | SRC PTyr530 | phosphorylation down-regulates ⊣ | SRC | 8755732 | SIGNOR-43315 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254726 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN21 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248725 |
| PTPN12 | dephosphorylation → up-regulates activity | SRC | SIGNOR-277086 |
| CSK | phosphorylation down-regulates | SRC | SIGNOR-179417 |
| FGR | phosphorylation → unknown | SRC | SIGNOR-251145 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248437 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248438 |
| CHKA | phosphorylation → down-regulates activity | SRC | SIGNOR-279731 |
| PTPN11 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248671 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248473 |
| PTPN21 | dephosphorylation → up-regulates | SRC | SIGNOR-124774 |
| PTPN1 | dephosphorylation → up-regulates | SRC | SIGNOR-103607 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248422 |
| PTPRE | dephosphorylation → up-regulates activity | SRC | SIGNOR-238074 |
| PTPRA | dephosphorylation → up-regulates | SRC | SIGNOR-32014 |
| PTPN6 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248472 |
| ACP1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248454 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-276977 |
| PTPRJ | dephosphorylation → up-regulates activity | SRC | SIGNOR-248705 |
| SRC | phosphorylation → down-regulates activity | SRC | SIGNOR-43315 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254726 |
