| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | SRC | Ser493 | CPPECPEsLHDLMCQ | phosphorylation up-regulates activity | 33388549 | SIGNOR-278444 |
| GSK3B | SRC | Ser493 | CPPECPEsLHDLMCQ | phosphorylation down-regulates activity | 33388549 | SIGNOR-277544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | SRC PSer493 | phosphorylation up-regulates → | SRC | 33388549 | SIGNOR-278444 |
| GSK3B | phosphorylation up-regulates → | SRC PSer493 | phosphorylation down-regulates ⊣ | SRC | 33388549 | SIGNOR-277544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → up-regulates activity | SRC | SIGNOR-278444 |
| GSK3B | phosphorylation → down-regulates activity | SRC | SIGNOR-277544 |