| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22482061 | SIGNOR-277009 |
| PTPRG | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254725 |
| PTPRJ | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 22898603 | SIGNOR-276978 |
| PTPN11 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 18482983 | SIGNOR-248670 |
| PTPN12 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 18482983 | SIGNOR-248659 |
| SRC | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates | 7578094 | SIGNOR-29369 |
| PDGFRB | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 15489898 | SIGNOR-247979 |
| PDGFRA | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 15489898 | SIGNOR-247984 |
| PTPRO | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation down-regulates activity | 25301722 | SIGNOR-277004 |
| PTK2 | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 17828307 | SIGNOR-278452 |
| PTPN1 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation up-regulates activity | 11007774 | SIGNOR-245299 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTEN | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22482061 | SIGNOR-277009 |
| PTPRG | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25624455 | SIGNOR-254725 |
| PTPRJ | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 22898603 | SIGNOR-276978 |
| PTPN11 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 18482983 | SIGNOR-248670 |
| PTPN12 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 18482983 | SIGNOR-248659 |
| SRC | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 7578094 | SIGNOR-29369 |
| PDGFRB | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 15489898 | SIGNOR-247979 |
| PDGFRA | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 15489898 | SIGNOR-247984 |
| PTPRO | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation up-regulates → | SRC | 25301722 | SIGNOR-277004 |
| PTK2 | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 17828307 | SIGNOR-278452 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation down-regulates ⊣ | SRC | 11007774 | SIGNOR-245299 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTEN | dephosphorylation → down-regulates activity | SRC | SIGNOR-277009 |
| PTPRG | dephosphorylation → down-regulates activity | SRC | SIGNOR-254725 |
| PTPRJ | dephosphorylation → down-regulates activity | SRC | SIGNOR-276978 |
| PTPN11 | dephosphorylation → down-regulates activity | SRC | SIGNOR-248670 |
| PTPN12 | dephosphorylation → down-regulates activity | SRC | SIGNOR-248659 |
| SRC | phosphorylation → up-regulates | SRC | SIGNOR-29369 |
| PDGFRB | phosphorylation → up-regulates activity | SRC | SIGNOR-247979 |
| PDGFRA | phosphorylation → up-regulates activity | SRC | SIGNOR-247984 |
| PTPRO | dephosphorylation → down-regulates activity | SRC | SIGNOR-277004 |
| PTK2 | phosphorylation → up-regulates activity | SRC | SIGNOR-278452 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-245299 |
