| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264885 |
| CyclinD/CDK4 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276084 |
| CyclinE/CDK2 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276099 |
| CyclinA2/CDK2 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276089 |
| PPM1D | UNG | – | dephosphorylation down-regulates activity | 15327777 | SIGNOR-277156 | |
| GSK3A | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264887 |
| CyclinD/CDK4 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276086 |
| GSK3A | UNG | Ser64 | EPGTPPSsPLSAEQL | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264886 |
| CyclinB/CDK1 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276092 |
| CyclinA2/CDK2 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276088 |
| CyclinB/CDK1 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276095 |
| CyclinD/CDK4 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276085 |
| CyclinA2/CDK2 | UNG | Ser64 | EPGTPPSsPLSAEQL | phosphorylation up-regulates activity | 18079698 | SIGNOR-276090 |
| CyclinE/CDK2 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276097 |
| CyclinA2/CDK2 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276091 |
| CyclinB/CDK1 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276093 |
| CyclinB/CDK1 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276096 |
| CyclinE/CDK2 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276098 |
| GSK3B | UNG | Ser64 | EPGTPPSsPLSAEQL | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264884 |
| CyclinB/CDK1 | UNG | Ser64 | EPGTPPSsPLSAEQL | phosphorylation up-regulates activity | 18079698 | SIGNOR-276094 |
| CyclinE/CDK2 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276100 |
| CyclinD/CDK4 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276087 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | UNG PThr60 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264885 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276084 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276099 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276089 |
| GSK3A | phosphorylation up-regulates → | UNG PThr60 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264887 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276086 |
| GSK3A | phosphorylation up-regulates → | UNG PSer64 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264886 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276092 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276088 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276095 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276085 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer64 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276090 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276097 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276091 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276093 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276096 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276098 |
| GSK3B | phosphorylation up-regulates → | UNG PSer64 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264884 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PSer64 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276094 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276100 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276087 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264885 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276084 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276099 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276089 |
| PPM1D | dephosphorylation → down-regulates activity | UNG | SIGNOR-277156 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264887 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276086 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264886 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276092 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276088 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276095 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276085 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276090 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276097 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276091 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276093 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276096 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276098 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264884 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276094 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276100 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276087 |
