Entity Details

Name CyclinD/CDK4_Ser12
ID P13051
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinA2/CDK2UNGSer12KTLYSFFsPSPARKRphosphorylation
up-regulates activity		18079698SIGNOR-276091
CyclinB/CDK1UNGSer12KTLYSFFsPSPARKRphosphorylation
up-regulates activity		18079698SIGNOR-276093
CyclinE/CDK2UNGSer12KTLYSFFsPSPARKRphosphorylation
up-regulates activity		18079698SIGNOR-276098
CyclinD/CDK4UNGSer12KTLYSFFsPSPARKRphosphorylation
up-regulates activity		18079698SIGNOR-276087
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinA2/CDK2phosphorylation
up-regulates
→
UNG
PSer12		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276091
CyclinB/CDK1phosphorylation
up-regulates
→
UNG
PSer12		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276093
CyclinE/CDK2phosphorylation
up-regulates
→
UNG
PSer12		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276098
CyclinD/CDK4phosphorylation
up-regulates
→
UNG
PSer12		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276087
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinA2/CDK2phosphorylation
→
up-regulates activity 		UNGSIGNOR-276091
CyclinB/CDK1phosphorylation
→
up-regulates activity 		UNGSIGNOR-276093
CyclinE/CDK2phosphorylation
→
up-regulates activity 		UNGSIGNOR-276098
CyclinD/CDK4phosphorylation
→
up-regulates activity 		UNGSIGNOR-276087