Entity Details

Name GSK3B_Thr60
ID P13051
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BUNGThr60AGQEEPGtPPSSPLSphosphorylation
down-regulates quantity by destabilization		27875297SIGNOR-264885
CyclinE/CDK2UNGThr60AGQEEPGtPPSSPLSphosphorylation
up-regulates activity		18079698SIGNOR-276099
GSK3AUNGThr60AGQEEPGtPPSSPLSphosphorylation
down-regulates quantity by destabilization		27875297SIGNOR-264887
CyclinD/CDK4UNGThr60AGQEEPGtPPSSPLSphosphorylation
up-regulates activity		18079698SIGNOR-276086
CyclinB/CDK1UNGThr60AGQEEPGtPPSSPLSphosphorylation
up-regulates activity		18079698SIGNOR-276095
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
UNG
PThr60		phosphorylation
down-regulates
⊣		UNG27875297SIGNOR-264885
CyclinE/CDK2phosphorylation
up-regulates
→
UNG
PThr60		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276099
GSK3Aphosphorylation
up-regulates
→
UNG
PThr60		phosphorylation
down-regulates
⊣		UNG27875297SIGNOR-264887
CyclinD/CDK4phosphorylation
up-regulates
→
UNG
PThr60		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276086
CyclinB/CDK1phosphorylation
up-regulates
→
UNG
PThr60		phosphorylation
up-regulates
→		UNG18079698SIGNOR-276095
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		UNGSIGNOR-264885
CyclinE/CDK2phosphorylation
→
up-regulates activity 		UNGSIGNOR-276099
GSK3Aphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		UNGSIGNOR-264887
CyclinD/CDK4phosphorylation
→
up-regulates activity 		UNGSIGNOR-276086
CyclinB/CDK1phosphorylation
→
up-regulates activity 		UNGSIGNOR-276095