| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264885 |
| CyclinE/CDK2 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276099 |
| GSK3A | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation down-regulates quantity by destabilization | 27875297 | SIGNOR-264887 |
| CyclinB/CDK1 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276095 |
| CyclinD/CDK4 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276086 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | UNG PThr60 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264885 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276099 |
| GSK3A | phosphorylation up-regulates → | UNG PThr60 | phosphorylation down-regulates ⊣ | UNG | 27875297 | SIGNOR-264887 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276095 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276086 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264885 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276099 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | UNG | SIGNOR-264887 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | UNG | SIGNOR-276095 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276086 |
