| Name | CFTR |
| ID | P13569 |
| Role | substrate |
| Enzymatic Domains |
ABC transmembrane type-1 1 81-365 PROSITE-ProRule
ABC transporter 1 423-646 PROSITE-ProRule
ABC transmembrane type-1 2 859-1155 PROSITE-ProRule
ABC transporter 2 1210-1443 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 10581361 | SIGNOR-72712 |
| PRKACA | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates | 1716180 | SIGNOR-21324 |
| PRKACA | CFTR | Ser795 | TASTRKVsLAPQANL | phosphorylation up-regulates | 1716180 | SIGNOR-21320 |
| PRKACA | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates activity | 1377674 | SIGNOR-250351 |
| PRKAA1 | CFTR | Ser737 | EPLERRLsLVPDSEQ | phosphorylation down-regulates activity | 19095655 | SIGNOR-259858 |
| PRKACA | CFTR | Ser737 | EPLERRLsLVPDSEQ | phosphorylation down-regulates activity | 19095655 | SIGNOR-21316 |
| PP1 | CFTR | – | dephosphorylation up-regulates activity | 21317537 | SIGNOR-264646 | |
| PRKG1 | CFTR | Ser795 | TASTRKVsLAPQANL | phosphorylation up-regulates | 1377674 | SIGNOR-18249 |
| PRKACA | CFTR | Ser700 | FGEKRKNsILNPINS | phosphorylation up-regulates activity | 1377674 | SIGNOR-250348 |
| STK39 | CFTR | – | phosphorylation down-regulates activity | 21317537 | SIGNOR-263134 | |
| PRKACA | CFTR | Ser768 | EPLERRLsLVPDSEQ | phosphorylation down-regulates activity | 19095655 | SIGNOR-18141 |
| PRKG1 | CFTR | Ser795 | TASTRKVsLAPQANL | phosphorylation up-regulates | 10581361 | SIGNOR-72724 |
| PRKACA | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 1716180 | SIGNOR-21312 |
| CSNK2A1 | CFTR | Ser511 | ENIIFGVsYDEYRYR | phosphorylation down-regulates | 21930781 | SIGNOR-176623 |
| CSNK2A1 | CFTR | Ser422 | NNNNRKTsNGDDSLF | phosphorylation up-regulates | 21930781 | SIGNOR-176619 |
| PRKG1 | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates | 10581361 | SIGNOR-72728 |
| AMPK | CFTR | Ser737 | EPLERRLsLVPDSEQ | phosphorylation down-regulates activity | 19095655 | SIGNOR-250350 |
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 1377674 | SIGNOR-18237 |
| CSNK2A1 | CFTR | Thr1471 | IAALKEEtEEEVQDT | phosphorylation down-regulates | 21930781 | SIGNOR-176627 |
| PRKAA1 | CFTR | Ser768 | LQARRRQsVLNLMTH | phosphorylation down-regulates activity | 19095655 | SIGNOR-259867 |
| STK39 | CFTR | – | phosphorylation down-regulates activity | 21317537 | SIGNOR-264643 | |
| PRKACA | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates activity | 1377674 | SIGNOR-250349 |
| PRKCA | CFTR | Ser790 | IHRKTTAsTRKVSLA | phosphorylation up-regulates activity | 1377674 | SIGNOR-248851 |
| PRKCA | CFTR | Ser686 | WTETKKQsFKQTGEF | phosphorylation up-regulates activity | 1377674 | SIGNOR-248849 |
| LMTK2 | CFTR | Ser737 | EPLERRLsLVPDSEQ | phosphorylation down-regulates activity | 24727471 | SIGNOR-278227 |
| PRKG1 | CFTR | Ser700 | FGEKRKNsILNPINS | phosphorylation up-regulates activity | 1377674 | SIGNOR-248850 |
| AMPK | CFTR | Ser768 | LQARRRQsVLNLMTH | phosphorylation down-regulates activity | 19095655 | SIGNOR-72708 |
| PRKG1 | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates | 1377674 | SIGNOR-18253 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72712 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 1716180 | SIGNOR-21324 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer795 | phosphorylation up-regulates → | CFTR | 1716180 | SIGNOR-21320 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-250351 |
| PRKAA1 | phosphorylation up-regulates → | CFTR PSer737 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-259858 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer737 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-21316 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer795 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18249 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer700 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-250348 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer768 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-18141 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer795 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72724 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1716180 | SIGNOR-21312 |
| CSNK2A1 | phosphorylation up-regulates → | CFTR PSer511 | phosphorylation down-regulates ⊣ | CFTR | 21930781 | SIGNOR-176623 |
| CSNK2A1 | phosphorylation up-regulates → | CFTR PSer422 | phosphorylation up-regulates → | CFTR | 21930781 | SIGNOR-176619 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72728 |
| AMPK | phosphorylation up-regulates → | CFTR PSer737 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-250350 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18237 |
| CSNK2A1 | phosphorylation up-regulates → | CFTR PThr1471 | phosphorylation down-regulates ⊣ | CFTR | 21930781 | SIGNOR-176627 |
| PRKAA1 | phosphorylation up-regulates → | CFTR PSer768 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-259867 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-250349 |
| PRKCA | phosphorylation up-regulates → | CFTR PSer790 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-248851 |
| PRKCA | phosphorylation up-regulates → | CFTR PSer686 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-248849 |
| LMTK2 | phosphorylation up-regulates → | CFTR PSer737 | phosphorylation down-regulates ⊣ | CFTR | 24727471 | SIGNOR-278227 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer700 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-248850 |
| AMPK | phosphorylation up-regulates → | CFTR PSer768 | phosphorylation down-regulates ⊣ | CFTR | 19095655 | SIGNOR-72708 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18253 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72712 |
| PRKACA | phosphorylation → up-regulates | CFTR | SIGNOR-21324 |
| PRKACA | phosphorylation → up-regulates | CFTR | SIGNOR-21320 |
| PRKACA | phosphorylation → up-regulates activity | CFTR | SIGNOR-250351 |
| PRKAA1 | phosphorylation → down-regulates activity | CFTR | SIGNOR-259858 |
| PRKACA | phosphorylation → down-regulates activity | CFTR | SIGNOR-21316 |
| PP1 | dephosphorylation → up-regulates activity | CFTR | SIGNOR-264646 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18249 |
| PRKACA | phosphorylation → up-regulates activity | CFTR | SIGNOR-250348 |
| STK39 | phosphorylation → down-regulates activity | CFTR | SIGNOR-263134 |
| PRKACA | phosphorylation → down-regulates activity | CFTR | SIGNOR-18141 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72724 |
| PRKACA | phosphorylation → up-regulates | CFTR | SIGNOR-21312 |
| CSNK2A1 | phosphorylation down-regulates | CFTR | SIGNOR-176623 |
| CSNK2A1 | phosphorylation → up-regulates | CFTR | SIGNOR-176619 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72728 |
| AMPK | phosphorylation → down-regulates activity | CFTR | SIGNOR-250350 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18237 |
| CSNK2A1 | phosphorylation down-regulates | CFTR | SIGNOR-176627 |
| PRKAA1 | phosphorylation → down-regulates activity | CFTR | SIGNOR-259867 |
| STK39 | phosphorylation → down-regulates activity | CFTR | SIGNOR-264643 |
| PRKACA | phosphorylation → up-regulates activity | CFTR | SIGNOR-250349 |
| PRKCA | phosphorylation → up-regulates activity | CFTR | SIGNOR-248851 |
| PRKCA | phosphorylation → up-regulates activity | CFTR | SIGNOR-248849 |
| LMTK2 | phosphorylation → down-regulates activity | CFTR | SIGNOR-278227 |
| PRKG1 | phosphorylation → up-regulates activity | CFTR | SIGNOR-248850 |
| AMPK | phosphorylation → down-regulates activity | CFTR | SIGNOR-72708 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18253 |